The relationship between adiponectin gene polymorphism and Thyroid Disorders at Zagazig University Hospitals
1 Shimaa Mohammed Ragab, Mohammed AlmhdyGamalAldeinKamar, Mohammed MohammedAwad, Mayada Mohammed Mousa
Background:Thyroid dysfunction is usually associated with changes in body weight, appetite and thermogenesis. The adiponectin gene has various Single Nucleotide Polymorphisms (SNPs). One of these SNPs is the 45T/G polymorphism encountered, in exon 2 of the adiponectin gene, has been frequently found its association with obesity, and breast cancer, and second rs1501299 (G276T) is in intron 2 of the ADIPOQ gene.The study aimed to identify the role of adiponectingene polymorphism in patients with thyroid disorders either hypothyroidism or hyperthyroidism.Methods:The study was carried out in endocrine outpatient clinic, internal medicine department, 150subjects were included in this study; they were divided into the following groups: Group1: Hypothyroid group. Group2: Hyperthyroid group. Participants were subjected to:Full history taking laboratory investigation: included Determination of adiponectin geneResults:there is no associations between ADIPO Q 276G>T SNP gene polymorphism and hypothyroidism & hyperthyroidism. Within hypothyroid group, there was statistically significant relation between gene polymorphism and both serum creatinine and albumin. Within hyperthyroid group, there was statistically significant relation between gene polymorphism and serum creatinine, urea, albumin and ALT, the difference was significant between GT and GG groups concerning both urea and albumin level and between GT group with both TT and GT groups concerning creatinine and between TT group and both GG and GT groups concerning ALT with non-significant relation between gene polymorphism and AST. Within hypothyroid group, there was statistically significant relation between gene polymorphism and both serum cholesterol and fasting blood glucose, the difference was significant between TT group and both GT and TT groups concerning cholesterol level. Within hyperthyroid group, there was statistically significant relation between gene polymorphism and both serum cholesterol, fasting and 2 hours postprandial blood glucose, the difference is significant between GT group and both GG and TT groups concerning cholesterol level.Conclusion:This study suggests that adiponectin gene polymorphism is not associated with thyroid dysfunctions among both groups of hypothyroidism& hyperthyroidism of Egyptian patients.
Adiponectin- Gene Polymorphism-Thyroid Disorder.