Role of Some Cytokines in Pathogenesis of Vitiligo

Vitiligo is an acquired hypomelanotic pigmentary disorders characterized by depigmented macules in the skin due to loss of melanocytes functions. The study aimed to detect levels of IL-10, IL-6 and IFN-ɤ. The study included 50 patients with age range between (8-63) year, 27 males and 23 females and 40 (20 males and 20 females apparently healthy control). Serum was separated and levels of cytokines above were detected by using enzyme linked Immunosorbent assay (ELISA). The results showed the average of patients age was 26.920 years and (10-20) age group was higher percentage of infection with vitiligo (46%), while less than 10 years age group was (4%). Family history positivity was 32% and results according to distribution of vitiligo lesion were generalized (56%), localized (35%) and universal (10%). The results of mean level of IL-10 showed significantly reducing (P<0.001) comparing with healthy control, and mean levels of IL-6 showed non-significantly increasing (P≥0.05) while mean levels of IFN-ɤ showed significantly increasing (P≤0.05). From these finding we can conclude that marked low serum leve of IL-10 and high serum level of IFN-ɤ and IL-6 in vitiligo patients clarify their important participation in the pathogenesis of vitiligo.