Activity of Monooxygenase and Nitrogenous Systems in Liver Microsomes Under the Influence of Inducers and Inhibitors of Medicinal Metabolism on the Organism in Conditions of Liver Pathology

1Sayfullaeva Saida1,Okhunov Alisher2, Jumanova Nargiza3

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Abstract:

In experiments on 48 white-breed rats of males with a mass of 180-250 g. it was found that benzonal in an effective dose of 75 mg/kg had a favorable effect on the monoxygenase and nitration system of hepatocyte microcircuits of rats with acute liver damage, while cimetidine in a dose of 10 mg/kg further suppressed the activity of MCO, increased the formation of toxic radicals NO, leading to an even greater aggravation of the severity of the animals.

Keywords:

monooxygenase, NO-system, benzonal, cimethedrine, hepatitis, nitrogen oxide, endothelial nitric oxide synthase, inducible nitrogen oxide synthase, peroxynitrite, cytochrome P450.

Paper Details
Month2
Year2020
Volume24
IssueIssue 2
Pages416-421