Synthesis, Characterization And Antibacterial Activity Of Azitidinone Containing Compounds

1Purav V. Talaviya

2J.A. Chaudhari

1Department of Chemistry, Shri Manilal Kadakia College of Commerce, Management, Science and Computer Studies.,
2Shri R. K. Parikh Arts & Science College Petlad, Gujarat

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Abstract:

The Schiff’s bases, 4-(substituted benzylidene amino)-N-(5-methylisoxazol-3-yl) benzene sulfonamide (3a-f) were papered from Sulphamethoxazole (1) and aromatic aldehydes (2a-f), then it were condensed with chloro acetyl chloride to yields 2-azitidinone derivatives, namely 4-(3-chloro-2-oxo-4-arylazetidin-1-yl)-N-(5-methylisoxazol-3-yl) benzene sulfonamide (4a-f). The (4a-f) were further treated with 1H-imidazole to 4-(3-(1H-imidazol-1-yl)-2-oxo-4-arylazetidin-1-yl)-N-(5-methylisoxazol-3-yl)benzenesulfonamide(6a-f). The derivatives (3a-f),(4a-f) and (6a-f) were characterized by elemental content and spectral features. Their antibacterial activity has also been monitored against common microbes.

Keywords:

Sulphamethoxazole, Schiff’s bases, 2-azitidinone, 1H-imidazole, elemental analysis, spectroscopy analysis and antibacterial activity.

Paper Details
Month01
Year2020
Volume24
IssueIssue 3
Pages7855-7860