Assessment of Serum Osteopontin Level in Children with Bronchial Asthma and its Relation to Disease Severity

1Mohammed SanadNagiub, Ehab Mahmoud Rasheed, AtefGoda Hussein, Ahmed IbraheemAbd El HameedAtya

167 Views
57 Downloads
Abstract:

Background:Many different mediators have been implicated in asthma and they may have a variety of effects on the airways which could account for all of the pathological features of allergic diseases. we aimed to assess Osteopontin(OPN) level in children with bronchial asthma.Methods:Our study done at Pulmonology unit Pediatric department of Zagazig University.Our study carried out on 190 children divided into 2 age groups ≤ 5 years and > 5 years. Each age group divided into 5 subgroups according to different severities of asthma into intermittent, mild, moderate and severe persistantasthma with healthy control group. serum OPN level were done for patients and controls.Results:we found that OPN show high significant difference between asthmatic and control group. Also, we reported that there was high significant difference between the control and asthmatic as Osteopontin in <5 age group and in 5-12 age group.At cut off point >14.8, area under the curve was 0.937, sensitivity was 97.8%, specificity 95.7%, PPV 96.4% and NPV 94.3%. Conclusion: The present study has shown that asthma patients exhibit higher serum OPN levels than controls.. Serum OPN is a promising biomarker in the diagnosis of bronchial asthma.

Keywords:

Osteopontin- bronchial asthma- Diagnosis.

Paper Details
Month12
Year2020
Volume24
IssueIssue 10
Pages6240-6248