AGING AND IMMUNE SYSTEM: AN OVERVIEW

1Sneha Kannan, N.P Muralidharan, Ganesh Lakshmanan

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Abstract:

The world is seeing a quick segment move towards a more established populace, a pattern with significant clinical, social, monetary and political ramifications. Maturing is a multifaceted procedure, including various sub-atomic and cell components with regards to various organ frameworks. An urgent part of maturing is a lot of useful and auxiliary adjustments in the invulnerable framework that can show as a diminished capacity to battle contamination, lessened reaction to inoculation, increased incidence of cancer, higher prevalence of autoimmunity and constitutive low- grade inflammation, among others. In addition to cell-intrinsic changes in both innate and adaptive immune cells, alteration in the stromal microenvironment in primary and secondary lymphoid organs plays an important role in age-associated immune dysfunction. This review will provide a broad overview of these phenomena and point out some of their clinical and therapeutic implications. This review study setting, discussing the gradual aging immune system. Data for this study is collected from different search engines like PubMed, Google Scholar, MeSH, Semantic scholar, Cochrane, NCBI, Medline, core science. A total of 53 articles were selected. The aging of the immune system is associated with dramatic changes in the distribution and competence of immune cells. Anti-Aging therapy should aim at prolonging T cells’ survival while weakening inflammation prone to innate immunity.

Keywords:

immune aging, t cells, DNA damage, immunosenescence, endocrine disorder, inflammation

Paper Details
Month11
Year2019
Volume23
IssueIssue 5
Pages1057-1065