Delineating the Physiological Mechanism of Neurological Disorder using Next Generation Sequencing

1Verma Pragya, Shakya Madhvi

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Abstract:

An amalgamation of genetic status and environmental disruptions seem to be accountable for the outbreak of Major depressive disorder (MDD), Schizophrenic psychosis, and Bipolar disorder. Additionally, the pathological mechanism of the illness is hypothesized to be neurodevelopmental. Recent studies of the nervous system mechanisms powerfully counsel that no single method is answerable for driving an extremely complicated process. In a nutshell, these findings counsel that combinatorial genetic and environmental factors that disturb a standard biological process in the early phase of life lead to molecular and histogenic outcomes that contribute to different biological process pathways and the clinical constitution identified accounting schizophrenic psychosis. In this paper, we manifest about recent NGS (Next Generation Sequencing) technology, which is widely utilized in transcriptome and genome-wide studies and is known to have high precision in finding critical factors associated with the neurological disorder.

Keywords:

Next Generation Sequencing, Major depressive disorder, Schizophrenic, Bipolar disorder, Transcriptome, Neurodegenerative disorder.

Paper Details
Month8
Year2020
Volume24
IssueIssue 10
Pages4719-4728