Immunological study on some of Psoriatic Iraqi PatientsTreated with Etanercept

1*Ghufran Qasem Abd-Alkhaliq, Wisal Salman Abd

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Abstract:

The present study is accomplished on (60) patients and (30) healthy individual. Serum levels of (Interleukin 17A (IL17A), Interleukin 17AR (IL17AR)and anticitrullinated protein antibody(ANTI-CCP) is estimated using Enzyme Linked Immunosorbent Assay (ELISA) technique and RF by latex test. Our results were high starting with IL17A mean value before treatment (967.24±784.1), IL17AR (818.62±647.33),ANTI-CCP (33.96±51.82) and with P value of (<0.0001). These levels were reduced significantly after treatment with (Etanercept) injection to give a mean levels of IL17A (360.61±302.38), IL17AR (118.67±191.85), ANTI-CCP (33.98±38.04) and with P value of (<0.0001).Patients were diagnosed with psoriasis arthritis (PsA) by calculating the degree of ANTI-CCP and results were 12 patients before treatment and 17 patients after treatment.ANTI-CCPwas important to diagnose PsA. IL17A, IL17AR have an important role in increasing the inflammation and as a marker for follow up after choosing a treatment in psoriasis and PsA.

Keywords:

Psoriasis, IL17A, IL17AR, Anti-CCP, RF

Paper Details
Month3
Year2020
Volume24
IssueIssue 4
Pages7747-7760