Oxidative Stress and Insulin Resistance Among Polycystic Ovary Syndrome Patients. A Cross-Sectional Study In Makassar, Indonesia

1Arlen Resnawaldi, Nusratuddin Abdullah, Samrichard Rambulangi, Firdaus Kasim, Masita Fujiko, Umar Malinta


This study aim to knowing the relationship between levels of oxidative stress on the incidence of insulin resistance in patients with Polycystic Ovary Syndrome (PCOS). This is Observational study with a crosssectional approach, samples of 27 patients with insulin resistance confirmed by IR HOMA > 2 and 27 patients without insulin resistance confirmed by HOMA IR < 2, then all subjects were tested for Reactive Oxygen Species (ROS) levels using the Enzyme-Linked Immunosorbent Assay (ELISA) method from January to December 2019. The average level of Reactive Oxygen Species (ROS) was 1.58, the average value of HOMA-IR was 2.91. There was a significant relationship between the ROS levels to the value of HOMA IR in patients with Polycystic Ovary Syndrome (PCOS) (p = 0.001; p <0.05). This study concludes that significant relationship between ROS and insulin resistance (HOMA-IR) is based on the mechanism of hyperglycemia due to insulin resistance resulting in increasing in Reactive Oxygen Species (ROS) which results in hyperandrogenic conditions in patients with Polycystic Ovary Syndrome (PCOS).


polycystic ovary syndrome, oxidative stress, insulin resistance

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IssueIssue 3