INFLUENCE OF SOME SULPHATED POLYSACCHARIDES ON THE PLATELET AGGREGATION IN NORMAL AND IN PATIENTS WITH ISCHEMIC HEART DISEASE

1Nasirov K.E., Musaeva M.K., Khoshimov N.N., Raimova G.M., Turaev A.S., Muhitdinov B.I.

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Abstract:

Purpose of the research: To study the effect of various modified sulfated polysaccharides on platelet aggregation activity in normal and in patients with coronary heart disease (CHD). Materials and methods: Platelet aggregation was recorded on a Biol ALAT-2 220LA aggregometer (Russia) on rich plasma of a healthy person and coronary heart disease. Platelet aggregation inducers used were ADP (2 μM), adrenaline (5 μM), and collagen and ristomycin (0.5 u / ml) (Sigma). Results: The degree of aggregation with the addition of ADP or adrenaline inducers in the blood plasma of a healthy person and coronary heart disease is shown, depending on. In contrast to ADP and adrenaline-induced aggregation, in collagen or ristomycin-induced aggregation, in the blood plasma of a healthy person and CHD, an almost identical single-phase, irreversible curve was observed, which shows that collagen and ristomycin-induced platelet aggregation do not change significantly. When studying the effect of compounds CC-BOS122, CC-GSC 63, CC-GSC-14 on platelet aggregation in healthy human plasma and coronary heart disease, it was shown that the compound CC-BOS-122 has the most pronounced activity. Conclusions: The studied compounds CCBOS-122, CC-GSC-63, and CC-GSC-14 have the greatest effect on the activity of glycoprotein receptors on the platelet membrane due to the mobilization of calcium ions from intracellular depots.

Keywords:

coronary heart disease, platelet glycoprotein receptors, platelet aggregation, sulfated polysaccharides.

Paper Details
Month5
Year2020
Volume24
IssueIssue 8
Pages6976-6985