Determination of Olmesartan Medoxomil In Bulk And Pharmaceutical Formulations By Validated RP-HPLC Method
1Dr Satyadev TNVSS, Dr M Madhu, V Sailaja, G.Hephzibah Dr T V Reddy
Analytical method was developed for the estimation of Olmesartan medoxomil drug substance by liquid chromatography. The chromatographic separation was achieved on Ascentris express C18 100*4.5um at ambient temperature. The separation was achieved by employing a mobile phase consisting of 0.1%v/v formic acid in water: Acetonitrile (50:50). The flow rate was 0.6 ml/ minute and UV detector was set at 230nm. The average retention time for Olmesartan medoxomil was found to be 1.9 min and the proposed method was validated for selectivity, precision, linearity and accuracy. All validation parameters were within the acceptable range. The assay methods were found to be linear in the range of 50-150µg/ml for Olmesartan medoxomil.
Olmesartan medoxomil, Isocratic, HPLC, Trifluoro acetic acid, and Acetonitrile