Spectrophotometric Determination of Clonazepam Drug in Pure form and Pharmaceutical Preparation by Diazotization Reaction

1Hajir S. Alteemi and Kassim H. Kadim

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Abstract:

By diazotization coupling reaction as accurate, selective and rapid spectrophotometric method for determination drug of clonazepam by reliant on azo-coupling reaction between CZP and 1,2-phenylenediamine for To achieve the purpose of obtaining the colored product with a maximum absorbance 480nm. For the conditions reaction have been studied and optimized. The linearity range for clonazepam was (0.1_6μg\ml) ,while the detections limit 0.04327and quantification limit 0.14425μg\ml The Molar Absorptivity 8.505×104 L/mol.cm with Sandal‘s sensitivity 0.00370 μg\cm2. Eventually this methods were successfully completed to determination of CZP in pure from and commercial form

Keywords:

Spectrophotometric Determination, Clonazepam, Azo-coupling Reaction

Paper Details
Month4
Year2020
Volume24
IssueIssue 5
Pages3808-3817