Sensitive and Simple Method for the Spectrophotometric Determination of Paracetamol Drug Using Oxidative Coupling

1Esraa M. Ridhaa, Duaa H. Sachit, Aseel M. Aljeboree and Ayad F. Alkaim


Background: Paracetamol is (N-acetyl-p-aminophenol) is famous as drug analgesic and drug antipyretic. Paracetamol is utilized global of antipyretic, analgesic activities. The spectrum of action the same of N.S.AI.D.s and particularly resembles the COX -2 inhibitors careful. Drug is, on typical, analgesic weak than N.S.AI.D.s or COX -2 inhibitors selective but is often desired because of its tolerance better. Thus, Paracetamol has to be detached from aqueous solution utilizing an effective way. However, study the object of the present to limited the affects of several conditions of the coupling oxidative color-metric systems for the determinations quantitative of Paracetamol. Methods: A highly and simple delicate optimal systems via utilizing spectrophotometric colorimetric way for the determination of Paracetamol utilizing the coupling oxidative reaction of 4AAP in the basic medium in found of potassium ferricyanide to give chromophore red-color which is spectrophotometrically limited at 510 nm. at temperature room . Under the recommended ideal conditions, law beer’s was obeyed the range conc. 10-100mgL- 1. Best linearity (r2=0.9988). Results: The good conc. of reagent was 0.01gm/100 ml and that of the potassium ferricyanide was 0.01gm/100 ml.


Spectrophotometry, Paracetamol, Oxidative Coupling, 4- aminoantipyrine, Potassium Ferricyanide, Colorimetric.

Paper Details
IssueIssue 5