Synthesis of New Gemcitabine Derivatives Linked Tetrazole Ring as Antibacterial Activity

1Ali Fattah Naser, Ammar Kareem Madlool, Dheyaa Hussein Mohsin, Ehab Kareem Obaid and Ali Jabbar Radhi

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Abstract:

A series of novel tetrazole derivatives contain nucleoside analog were synthesized by reaction between azido gemcitabine with nitrile compounds in presence ammonium chloride as catalyst. The structures of all prepared compounds were analyzed by NMR and FTIR spectroscopic methods. The antibacterial activity of tetrazole derivatives were determined by using Streptococcus Pneumonia and Escherichia Coli, Staphylococcus aureus.

Keywords:

Antibacterial Activity, Gemcitabine, Tetrazole, Heterocyclic.

Paper Details
Month3
Year2020
Volume24
IssueIssue 5
Pages1806-1813