Antibiotic Therapy for Early Ages and Asthma Development in School Children

1Roberth Zambrano Ubillus, Fanny Solorzano Torres, Aida Macias Alvia and Jenny Vargas Santos

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Abstract:

The objective of the research was to determine the association between the use of antibiotics in Early ages and the development of asthma at school age, this study is a retrospective observational descriptive approach with a quantitative case-control approach. Medical records of patients from the pediatric area of a Guayaquil hospital were reviewed. The total sample was 366 children. The cases (n = 183) were chosen from the hospital database of children between 5 and 12 years old who have been diagnosed with asthma. Controls were matched in equal numbers and proportions. 43% of the cases used antibiotic therapy before 5 years, with amoxicillin being the most beta-lactamase inhibitor, the most widely used antibiotic (28.8%). The most frequent comorbidity was acute upper respiratory infection (38%). Among the controls, the most used antibiotic corresponded to amoxicillin (34.8%), while the most frequent infection was the same as for the cases (50.0%). An analysis was performed to determine if the difference in distribution concerning the use of antibiotics is significant between cases and controls and it was determined that there is a much higher percentage of antibiotic use in cases than in controls (60.1% vs. 25.7% ; p = 0.011). The analysis reflects an association between the use of antibiotics at an early age and the appearance of asthma at school age. Thus, the use of antibiotics in children under 5 years increases the risk 4.5 times of having asthma at school age.

Keywords:

Antibiotics, Asthma, Children, Immune System, Intestinal Microbiome.

Paper Details
Month3
Year2020
Volume24
IssueIssue 5
Pages944-956