Pathogenetic Value of Cytokine Production in HIV Infection

1Allabergen Bayjdanov, Sokhiba Utegenova

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Abstract:

Against the background of the progression of HIV infection, there is an imbalance in the production of cytokines, characterized by the switching of the TV-1 response to TV-2. As the disease progresses, the prevalence of anti-inflammatory cytokines produced by Th-2 cells is observed, which shows the aggravation of immunosuppression and the development of opportunistic diseases. It was revealed that IL-2, IL-4 and IL-10 might have a multidirectional action depending on local conditions. Thus, cytokines can serve as markers for predicting the progression of HIV infection.

Keywords:

cytokines, interleukin-2, interleukin-10, HIV infection, CD4+ lymphocytes.

Paper Details
Month2
Year2020
Volume24
IssueSpecial Issue 1
Pages811-814