Possible Pathogenetic Mechanisms of Progression and the Occurrence of Intellectual and Cognitive Impairment in Patients with Down Syndrome

1Yakutkhon Madjidova, Saodatkhon Salikhova

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Abstract:

Down syndrome often have multiple abnormalities, such as muscle hypotension, physical, mental, speech, hearing problems, congenital heart defects. In research we have observed 36 children with Down syndrome aged 3 to 8 years (16 girls, 20 boys). All cases of the disease were confirmed genetically; all had complete trisomy on 21 chromosomes. Patients were examined by a neurologist, pediatrician, audiologist, dentist, cardiologist and neuropsychologist. Thus, the results of our studies confirm that with Down syndrome, an intellectual defect is combined with damage to a number of systems such as cardiovascular, auditory, speech, etc.

Keywords:

Down Syndrome, intellectual and cognitive impairment, the Stanford Binet scale, children.

Paper Details
Month2
Year2020
Volume24
IssueSpecial Issue 1
Pages789-793