Correlation between vascular endothelial growth factor expression and cervical lymph node carcinoma

1Miatina Artisnita Arisakti, Muhtarum Yusuf


Introduction, Recent experimental evidence indicates that angiogenesis affects tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is considered to be an important regulator of tumor angiogenesis. The present study was designed to examine the role of VEGF on cervical lymph node metastasis in primary nasopharyngeal carcinomas (NPCs). Methods: Formalin-fixed paraffin-embedded biopsy specimens were obtained from 36 primary NPC with histologically undifferentiated carcinomas and clinically divided into four cervical lymph node status, i.e. N0, N1, N2 and N3. The expression of VEGF was observed with immunohistochemistry involving rabbit polyclonal antibody Anti Human VEGF-A (Biocare Medical, LLC, USA). Assessment of the staining was performed by two independent observers who had no knowledge of the clinical background of the patients. Mann-Whitney U test was used to determine the correlation between the expression of VEGF and cervical lymph node status. Statistical significance was defined as p < 0.05.Results:VEGF expression in NPC based on cervical lymph node status, for weak VEGF expression was 83.33% for all samples, followed by moderate VEGF expression with16.67%. From the Mann-Whitney U-test result, it was found that pwas0.058. There was no significant correlation between VEGF expression and cervical lymph node status (p > 0.05). Conclusion: There was no correlation between the increase of VEGF expression and cervical lymph node enlargement in nasopharyngeal carcinoma.


Cervical lymph node, growth factor expression, nasopharyngeal carcinoma, vascular endothelial

Paper Details
IssueIssue 2