Synthesis of Some Substituted Analogues of Natural Flavones and Chalcones

1Gulzira Ismailova, Shakhnoza Abzalova, Zulfiya Ikramova, Bakhromkhodja Aykhodjaev, Sabirdjan Arifdjanov

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Abstract:

Using modified methods, we synthesized some substituted analogues of natural flavones with the formation of a chromon system (method A using DMSO in the presence of copper (II) bromide and method B in the presence of copper (II) chloride), as well as chalcones using the Kleisen-Schmidt method and the use of phenyla-cetic acid. Some physicochemical constants of the synthesized compounds are given, structures on the PMR spec-trum and Tesla BS-567A are established, the crystallographic parameters of single crystals are determined and re-fined on a «Xcalibur» CCD diffractometer, which may make it possible to obtain compounds with useful biological properties for further use them in chemical modification.

Keywords:

synthesis, flavones, chalcones, structures, crystallographic parameters.

Paper Details
Month2
Year2020
Volume24
IssueSpecial Issue 1
Pages840-844

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