Occurrence of Clinical Options of Undifferentiated Connective Tissue Dysplasia in Uzbek Population
11Shodikulova Gulandon Zikrievna, 2Babamuradova Zarrina Bakhtiyarovna
Object: To study the occurrence of clinical variants of undifferentiated connective tissue dysplasia (NDST) in the Uzbek population. Methods: 105 individuals were examined, including 49 (46.4%) males and 56 (53.6%) females aged 15 to 28 (20.13 ± 0.66) years with signs of NDCT. Findings: The incidence of NDCT in women is within 40%, in males 66.0%. An analysis of the distribution of NDST by place of residence showed a slight predominance of city residents (60 patients lived in the city, 45 in the countryside), an increase in the frequency of HLA gene class II was observed: HLA DRB1 *, DQA1 * 04: 01 and DQB1 * 04: 01/2 . The incidence of clinical options is joint hypermobility (100%), changes in the shape of the spine (44%), chest (43.8%), skin extensibility of varying severity (38.8%), small developmental anomalies (21.1%) and flat feet (20.4%). The frequency of combinations of external hair dryers: a combination of 6 revealedat 5 (4,5%), 5-th – at 11 (10%), 4-th – at 21 (20%), 3-rd – at 26 (24,3%), 2-nd – at 31 (30,6%) examined Conclusions: Thus, the early detection of signs of NDCT in young people among the Uzbek population will optimize early diagnosis and predict the outcome of the disease.
undifferentiated connective tissue dysplasia, clinical options, external and internal hair dryers, HLA system.