ACCELERATED TOOTH MOVEMENT USING PLASMA RICH PROTEIN-A CRITICAL REVIEW
DOI:
https://doi.org/10.61841/5vgpp068Keywords:
Orthodontic tooth movement, alveolar bone density, osteoclastAbstract
The accessibility of orthodontic treatment has increased the number of patients opting for the treatment. Orthodontic treatment has shown to improve the overall well-being of the patient. Still, there are many disadvantages to orthodontic treatmentof which patient acceptability to prolonged orthodontic treatment is of primary concern. Many surgical and non-surgical methods have been developed and employed to hasten the treatment. Amongst various methods used this review article will highlight the use of protein rich plasma(PRP) as an adjunct to accelerate tooth movement, which acts by the changing the alveolar bone density due to the presence of osteoclast.
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1) Tsichlaki A, Chin SY, Pandis N, Fleming PS. How long does treatment with fixed orthodontic appliances last? A systematic review. American journal of orthodontics and dentofacialorthopedics. 2016 Mar 1;149(3):308-18.
2) Majithia PS, Mascarenhas R, Husain A. Comparison of treatment duration in different malocclusions. Archives of Medicine and Health Sciences. 2013 Jan 1;1(1):59.
3) Talic NF. Adverse effects of orthodontic treatment: a clinical perspective. The Saudi dental journal. 2011 Apr 1;23(2):55-9.
4) Krishnan V, Davidovitch Z. On a path to unfolding the biological mechanisms of orthodontic tooth movement. Journal of dental research. 2009 Jul;88(7):597-608.
5) Frost HM . The regional acceleratory phenomenon. OrthopClin North Am 1981;12:725-6.
6) Verna C. Regional acceleratory phenomenon. InTooth Movement 2016 (Vol. 18, pp. 28-35). Karger Publishers.
7) Uzuner FD, Darendeliler N. Dentoalveolar surgery techniques combined with orthodontic treatment: A literature review. European Journal of Dentistry. 2013 Apr;7(02):257-65.
8) Gkantidis N, Mistakidis I, Kouskoura T, Pandis N. Effectiveness of non-conventional methods for accelerated orthodontic tooth movement: a systematic review and meta-analysis. Journal of Dentistry. 2014 Oct 1;42(10):1300-19.
9) Qamruddin I, Alam MK, Mahroof V, Fida M, Khamis MF, Husein A. Effects of low-level laser irradiation on the rate of orthodontic tooth movement and associated pain with self-ligating brackets. American Journal of Orthodontics and DentofacialOrthopedics. 2017 Nov 1;152(5):622-30.
10) Leethanakul C, Suamphan S, Jitpukdeebodintra S, Thongudomporn U, Charoemratrote C. Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement. The Angle Orthodontist. 2016 Jan;86(1):74-80.
11) Kalemaj Z, DebernardI CL, Buti J. Efficacy of surgical and non-surgical interventions on accelerating orthodontic tooth movement: a systematic review. European journal of oral implantology. 2015;8(1):9.
12) Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP?. Implant dentistry. 2001 Dec 1;10(4):225-8.
13) Marx RE. Platelet-rich plasma: evidence to support its use. Journal of oral and maxillofacial surgery. 2004 Apr 1;62(4):489-96.
14) Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 1998 Jun 1;85(6):638-46.
15) El‐Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, Van Dyke TE. Platelet‐rich plasma: growth factors and pro‐and anti‐inflammatory properties. Journal of periodontology. 2007 Apr;78(4):661-9.
16) C. Verna, M. Dalstra, B. Melsen, “The rate and the type of orthodontic tooth movement is influenced by bone turnover in a rat model,” European Journal of Orthodontic, vol. 22, pp. 343- 352, 2000.
17) ErlieraErlieraSufarnap et al. The Effect of PlateletRich Plasma to Orthodontic Tooth Movement. Advances in Health Science Research, vol 8, 80- 83,2018.
18) Liou EJ. The development of submucosal injection of platelet rich plasma for accelerating orthodontic tooth movement and preserving pressure side alveolar bone. APOS trends in orthodontics. 2016 Jan 11;6(1):5-11.
19) Güleç A, Bakkalbaşı BÇ, Cumbul A, Uslu Ü, Alev B, Yarat A. Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: A histomorphometric study. American Journal of Orthodontics and DentofacialOrthopedics. 2017 Jan 1;151(1):92-104.
20) Rashid A, ElSharaby FA, Nassef EM, Mehanni S, Mostafa YA. Effect of platelet‐rich plasma on orthodontic tooth movement in dogs. Orthodontics & Craniofacial Research. 2017 May;20(2):102-10.
21) Akbulut S, Yagci A, Yay AH, Yalcin B. Experimental investigation of effects of platelet-rich plasma on early phases of orthodontic tooth movement. American Journal of Orthodontics and DentofacialOrthopedics. 2019 Jan 1;155(1):71-9.
22) Güleç A, Cumbul A, Uslu Ü, Bakkalbaşı BÇ. The effects of local platelet-rich plasma (PRP) injection on orthodontic tooth movement using the Cavalieri’s principle. ActaStereologica. 2015 Jul 9.
23) El-Timamy A, El Sharaby F, Eid F, El Dakroury A, Mostafa Y, Shaker O. Effect of platelet-rich plasma on the rate of orthodontic tooth movement: A split-mouth randomized trial. The Angle Orthodontist. 2020 May 1;90(3):354-61.
24) Vassbotn FS, Havnen OK, Heldin CH, Holmsen H. Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. Journal of Biological Chemistry. 1994 May 13;269(19):13874-9.
25) Miyazono K. Positive and negative regulation of TGF-beta signaling. Journal of cell science. 2000 Apr 1;113(7):1101-9.
26) Gupta C, Mehrotra D, Mohammad S, Khanna V, Singh GK, Singh G, Chellappa AA, Passi D. Alveolar bone graft with Platelet Rich Plasma in cleft alveolus. Journal of oral biology and craniofacial research. 2013 Jan 1;3(1):3-8.
27) Giudice G, Cutrignelli DA, Leuzzi S, Robusto F, Sportelli P, Nacchiero E. Autologous bone grafting with platelet-rich plasma for alveolar cleft repair in patient with cleft and palate. Ann ItalChir. 2016 Jan 1;87:5-12.
28) Sakio R, Sakamoto Y, Ogata H, Sakamoto T, Ishii T, Kishi K. Effect of platelet-rich plasma on bone grafting of alveolar clefts. Journal of Craniofacial Surgery. 2017 Mar 1;28(2):486-8.
29) Oyama T, Nishimoto S, Tsugawa T, Shimizu F. Efficacy of platelet-rich plasma in alveolar bone grafting. Journal of oral and maxillofacial surgery. 2004 May 1;62(5):555-8.
30) Lee C, Nishihara K, Okawachi T, Iwashita Y, Majima HJ, Nakamura N. A quantitative radiological assessment of outcomes of autogenous bone graft combined with platelet-rich plasma in the alveolar cleft. International journal of oral and maxillofacial surgery. 2009 Feb 1;38(2):117-25.
31) Shi B, Zhou Y, Wang YN, Cheng XR. An experimental study on alveolar ridge preservation prior to dental implant placement. Zhonghuakouqiangyixuezazhi= Zhonghuakouqiangyixuezazhi= Chinese journal of stomatology. 2006 Feb;41(2):114-5.
32) Kim YS, Kwon KH, Cha SY, Min SK. Effect of gelatin spongy and platelet rich plasma on ridge preservation and bone formation after extraction. Maxillofacial Plastic and Reconstructive Surgery. 2005;27(3):238-47.
33) Ali Mahmood TM, Chawshli OF. The Effect of Submucosal Injection of Plasma-Rich Platelets on Blood Inflammatory Markers for Patients with Bimaxillary Protrusion Undergoing Orthodontic Treatment. International journal of inflammation. 2019 Oct 1;2019.
34) McBride MD, Campbell PM, Opperman LA, Dechow PC, Buschang PH. How does the amount of surgical insult affect bone around moving teeth? Am J OrthodDentofacialOrthop 2014;145 4 Suppl: S92-9.
35) Nimeri G, Kau CH, Abou-Kheir NS, Corona R. Acceleration of tooth movement during orthodontic treatment-a frontier in orthodontics. Progress in orthodontics. 2013 Dec 1;14(1):42.
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