AWARENESS OF INTERFERON THERAPY AMONG DENTAL STUDENTS

Authors

  • Nithyanandham Masilamani Tutor, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, India Author
  • Dhanraj Ganapathy Professor &Head of Department, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, India Author

DOI:

https://doi.org/10.61841/ax25gv33

Keywords:

Awareness, interferon therapy, dental students

Abstract

Interferon is perhaps the term given to antiviral material formed by many vertebrate cells in reaction to viral infections. Research has established a number of mechanisms involved, in therapeutic benefits of interferon together with antiviral, innate immunity-enhancing and cytostatic functions.This survey was performed for assessing the awareness about interferon therapy amongst dental students. A cross sectional survey was performed with a self-administered questionnaire with 10 queries circulated among 100 dental students. The questionnaire assessed the awareness about Interferon therapy,their medicinal uses,anticancer activity,mechanism of action and side effects.The responses were recorded and analysed.91% of the respondents were not aware of medical uses of Interferon therapy .93% were not aware of anticancer activity of Interferon therapy .93 % were not aware of the mechanism of action of Interferon therapy .96% were not aware of side effects of Interferon therapy. The awareness about the use of interferon therapy is very less among dental students.Increased awareness programs and sensitization programs should be conducted to improve the awareness levels.

Downloads

Download data is not yet available.

References

1. Aguet, M., Gröbke, M., & Dreiding, P. (1984). Various human interferon a subclasses cross-react with common receptors: Their binding affinities correlate with their specific biological activities. Virology, 132(1), 211–216. https://doi.org/10.1016/0042-6822(84)90105-3

2. Bart, R. S., Kopf, A. W., & Silagi, S. (1971). Inhibition of the Growth of Murine Malignant Melanoma by Polyinosinic-Polycytidylic Acid. Journal of Investigative Dermatology, 56(1), 33–38. https://doi.org/10.1111/1523-1747.ep12291892

3. Dittmer, D. P., & Krown, S. E. (2010). Molecular Basis for Therapy of AIDS-Defining Cancers. Springer Science & Business Media.

4. Evans, E. A., & Anthony Evans, E. (1992). Biologic therapy of cancer. Editors V T DeVita (Jr), S Hellman and S A Rosenberg Pub: J B Lippincott company, Philadelphia, USA, 1991, pp 816 price: US $125.00 ISBN 0-397-51027-6. Journal of Labelled Compounds and Radiopharmaceuticals, 31(1), 79–80. https://doi.org/10.1002/jlcr.2580310111

5. Golomb, H. M., Jacobs, A., Fefer, A., Ozer, H., Thompson, J., Portlock, C., Ratain, M., Golde, D., Vardiman, J., & Burke, J. S. (1986). Alpha-2 interferon therapy of hairy-cell leukemia: a multicenter study of 64 patients. Journal of Clinical Oncology, 4(6), 900–905. https://doi.org/10.1200/jco.1986.4.6.900

6. Isaacs, A., & Lindenmann, J. (1987). Virus interference. I. The interferon. Journal of Interferon Research, 7(5), 429–438. https://doi.org/10.1089/jir.1987.7.429

7. Kioke, O., Wandl, U., Opalka, B., Moritz, T., Nagel-Hiemke, M., Franz, T., Becher, R., Hirche, H., Seeber, S., & Niederle, N. (2009). A prospective randomized comparison of single-agent interferon (IFN) alpha with the combination of IFN-alpha and low-dose IFN-gamma in chronic myelogenous leukaemia. European Journal of Haematology, 48(2), 93–98. https://doi.org/10.1111/j.1600-0609.1992.tb00572.x

8. Kirkwood, J. M., Strawderman, M. H., Ernstoff, M. S., Smith, T. J., Borden, E. C., & Blum, R. H. (1996). Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. Journal of Clinical Oncology, 14(1), 7–17.

9. Kurzrock, R., Talpaz, M., Kantarjian, H., Walters, R., Saks, S., Trujillo, J. M., & Gutterman, J. U. (1987). Therapy of chronic myelogenous leukemia with recombinant interferon-gamma. Blood, 70(4), 943–947. https://doi.org/10.1182/blood.v70.4.943.bloodjournal704943

10. Merlin, G., Falcoff, E., & Aguet, M. (1985). 125I-labelled Human Interferons Alpha, Beta and Gamma: Comparative Receptor-binding Data. Journal of General Virology, 66(5), 1149–1152. https://doi.org/10.1099/0022-1317-66-5-1149

11. Nomenclature, O., & Mouse, H. (1980). Interferon nomenclature. Nature, 286, 10.

12. Pyrhönen, S., Salminen, E., Ruutu, M., Lehtonen, T., Nurmi, M., Tammela, T., Juusela, H., Rintala, E., Hietanen, P., & Kellokumpu-Lehtinen, P.-L. (1999). Prospective Randomized Trial of Interferon Alfa-2a Plus Vinblastine Versus Vinblastine Alone in Patients With Advanced Renal Cell Cancer. Journal of Clinical Oncology, 17(9), 2859–2859. https://doi.org/10.1200/jco.1999.17.9.2859

13. Quesada, J. R., Reuben, J., Manning, J. T., Hersh, E. M., & Gutterman, J. U. (1984). Alpha Interferon for Induction of Remission in Hairy-Cell Leukemia. New England Journal of Medicine, 310(1), 15–18. https://doi.org/10.1056/nejm198401053100104

14. Real, F. X., Oettgen, H. F., & Krown, S. E. (1986). Kaposi’s sarcoma and the acquired immunodeficiency syndrome: treatment with high and low doses of recombinant leukocyte A interferon. Journal of Clinical Oncology, 4(4), 544–551. https://doi.org/10.1200/jco.1986.4.4.544

15. Sawyer, L. A., Metcalf, J. A., Zoon, K. C., Boone, E. J., Kovacs, J. A., Clifford Lane, H., & Quinnan, G. V. (1990). Effects of interferon-α in patients with aids-associated Kaposi’s sarcoma are related to blood interferon levels and dose. Cytokine, 2(4), 247–252. https://doi.org/10.1016/1043-4666(90)90024-n

16. Walter, M. R., Bordens, R., Nagabhushan, T. L., Williams, B. R. G., Herberman, R. B., Dinarello, C. A., Borden, E. C., Trotta, P. P., Pestka, S., & Pfeffer, L. M. (1998). Review of Recent Developments in the Molecular Characterization of Recombinant Alfa Interferons on the 40th Anniversary of the Discovery of Interferon. Cancer Biotherapy and Radiopharmaceuticals, 13(3), 143–154. https://doi.org/10.1089/cbr.1998.13.143

17. Ward, T. T. (1986). AIDS and Other Medical Problems in the Male Homosexual.

Downloads

Published

03.12.2019

Issue

Vol. 23 No. 6 (2019): 23 (6) 2019

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  2. Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .

No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

How to Cite

Masilamani, N., & Ganapathy, D. (2019). AWARENESS OF INTERFERON THERAPY AMONG DENTAL STUDENTS . International Journal of Psychosocial Rehabilitation, 23(6), 1038-1044. https://doi.org/10.61841/ax25gv33