INFLUENCE OF SOME SULPHATED POLYSACCHARIDES ON THE PLATELET AGGREGATION IN NORMAL AND IN PATIENTS WITH ISCHEMIC HEART DISEASE

Authors

  • Nasirov K.E. Institute of Biophysics and Biochemistry at the National University of Uzbekistan Author
  • Musaeva M.K Institute of Biophysics and Biochemistry at the National University of Uzbekistan Author
  • Khoshimov N.N Institute of Biophysics and Biochemistry at the National University of Uzbekistan Author
  • Raimova G.M Institute of Biophysics and Biochemistry at the National University of Uzbekistan Author
  • Turaev A. S Institute of Biophysics and Biochemistry at the National University of Uzbekistan Author
  • Muhitdinov B.I. Institute of Bioorganic Chemistry named after academician A.S. Sadykov Uzbek Academy of Sciences Author

DOI:

https://doi.org/10.61841/qbrrwp27

Keywords:

coronary heart disease, platelet glycoprotein receptors, platelet aggregation, sulfated polysaccharides.

Abstract

Purpose of the research: To study the effect of various modified sulfated polysaccharides on platelet aggregation activity in normal and in patients with coronary heart disease (CHD). Materials and methods: Platelet aggregation was recorded on a Biol ALAT-2 220LA aggregometer (Russia) on rich plasma of a healthy person and coronary heart disease. Platelet aggregation inducers used were ADP (2 μM), adrenaline (5 μM), and collagen and ristomycin (0.5 u / ml) (Sigma). Results: The degree of aggregation with the addition of ADP or adrenaline inducers in the blood plasma of a healthy person and coronary heart disease is shown, depending on. In contrast to ADP and adrenaline-induced aggregation, in collagen or ristomycin-induced aggregation, in the blood plasma of a healthy person and CHD, an almost identical single-phase, irreversible curve was observed, which shows that collagen and ristomycin-induced platelet aggregation do not change significantly. When studying the effect of compounds CC-BOS-122, CC-GSC-63, CC-GSC-14 on platelet aggregation in healthy human plasma and coronary heart disease, it was shown that the compound CC-BOS-122 has the most pronounced activity. Conclusions: The studied compounds CC-BOS-122, CC-GSC-63, and CC-GSC-14 have the greatest effect on the activity of glycoprotein receptors on the platelet membrane due to the mobilization of calcium ions from intracellular depots.

 

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Published

31.10.2020

Issue

Vol. 24 No. 8 (2020): 24 (8) 2020

Section

Articles

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How to Cite

K.E., N., M.K, M., N.N, K., G.M, R., S, T. A., & B.I., M. (2020). INFLUENCE OF SOME SULPHATED POLYSACCHARIDES ON THE PLATELET AGGREGATION IN NORMAL AND IN PATIENTS WITH ISCHEMIC HEART DISEASE. International Journal of Psychosocial Rehabilitation, 24(8), 6976-6985. https://doi.org/10.61841/qbrrwp27