Study of Serum Concentrations of Omentin-1 in Children with Type 1 Diabetes as Indicator of Insulin Resistance at Zagazig University Hospital
Background:Diabetes mellitus (DM) is characterized by a set of metabolic disorders which are related to high blood sugar levels over a lengthy interval of time and may cause many complications. Omentin-1 is an important anti-inflammatory adipokine produced preferentially in visceral adipose tissue. It has been reported that circulating levels of omentin-1 are related to insulin resistance, obesity, dyslipidemia, endothelial dysfunction, arterial hypertension and so on. The aim was to assess omentin-1 in serum of children with type 1 diabetes, relevant to the disease duration. Methods: This case control prospective study that carried out in endocrinology unit and outpatient clinic at Pediatric Department, Zagazig University Hospital on 85 (17 in every group). Serum omentin-1 level was measured. Results:Regard omentin control group were significantly lower than other groups and group 4 were significantly higher than other groups also group 2&3 were sig higher than group1.Significant AUC with cutoff >191.7 and 100.0% sensitivity and specificity. Regard FBS & PPBS control group were significantly lower than other groups but group 4 were significantly higher than other groups regard PPBS, Regard HA1C control group were significantly lower than other groups but group 1&4 were significantly higher than other groups .Conclusion: increased omentin-1 levels are associated with increasing obesity hormonal disturbance state (early puberty) and insulin resistance. Therefore, omentin-1 levels may be predictive of the metabolic consequences or co-morbidities associated with type 1 DM. The mechanism and physiological role of omentin-1 in glucose metabolism is not well understood. Further investigation is needed to determine whether omentin-1 can act as a link between obesity and diabetes. Omentin-1 serum levels act as a predictor of development of insulin resistance and diabetes and should be further investigated.