Role of Hyperuricemiaand Red Cell Distributionwidth inAssessment of RenalMicrovascularDamage in Patients with Systemic Sclerosis

Objectives:The aim of our study was noninvasive assessment of renal microvascular damage in patients with systemic sclerosis by studying correlation between serum uric acid / red cell distribution width and intrarenal arterial stiffness evaluated by Doppler ultrasound and relation between red cell distribution width and renal function. Method:This is a cross sectional study that was carried out in Rheumatology and Rehabilitation department, Faculty of Medicine, Zagazig University Hospitals on 44 Systemic Sclerosis patients. These patients were subjected to detailed history, clinical and rheumatological examinations, lab investigations; complete blood picture, erythrocyte sedimentation rate, C reactive protein, antinuclear antibody, kidney functions, liver functions and serum uric acid and Doppler ultrasound of intrarenal arteries with evaluation of resistive index, pulsatile index and systolic / diastolic ratio. Result:The serum uric acid showed significant positive correlation with Doppler indices, serum creatinine, creatinine clearance and blood urea nitrogen and negative correlation with chronic kidney disease epidemiology collaboration (CKD-EPI). Red cell distribution width showed significant positive correlation with Doppler indices, serum creatinine, creatinin clearance and blood urea nitrogen and negative correlation with CKD-EPI and mean corpuscular volume (MCV). Conclusion:Uric acid and red cell distribution width are valuable markers in detection of renal microvascular damage in patients with Systemic Sclerosis. Also, kidney affection was more obvious in diffuse systemic sclerosis than limited.