Impact ofTotal Parenteral nutritionon Outcomes of Neonatal Intensive Care Units

Background:Total Parenteral nutrition (TPN) can be life saving for neonates who cannot receive adequate enteral nutrition because of inability to tolerate enteral feeds.The ASPEN’s standards of practice participate in the development, implementation and has provided excellent guidelines to address each of the components of TPN. The objectives of this work were to determine the outcomes of neonates on total parenteral nutrition prepared without laminar (retrograde) or prepared with laminar unit.Methods:This retrospective prospective cohort study included 420 neonates, the without laminar group cases where TPN is prepared on ward include (150) and the laminar group cases where TPN prepared is on TPN unit using laminar flow include (270).All neonates in our study were subjected to full history taking, clinical examination, laboratory investigations on admission and on discharge and the protocol of treatment according to unit protocol. Results:There is significant difference between 2 groups as regard presence of maternal history and as regard PROM.There is high significant difference between 2 groups as regard Hb, CRP, and Ca level on discharge there is increase in the laminar group.There is high significant difference between 2 groups as regard short term outcome, neurodevelopmental delay and as regard bronchopulmonary dysplasia.There is high significant difference between 2 groups as regard Develop sepsis and as regard weight on discharge. Conclusion: Using laminar flow in TPN preparation decrease mortality rate ,occurrence of neurodevelopmental delay ,bronchopulmonary dysplasia.