PREVALENCE OF MALNUTRITIONINflAMMATION COMPLEX SYNDROME IN HEMODIALYSIS PATIENTS AND ITS CORRELATION WITH CHANGES IN SERUM THYROID HORMONES
Mohamed Omar Al sayed Ali, Mohammed Ali Fahmy El Zanaty, Tamer Mohamed Goda
Background: Low levels of thyroid hormones, total triiodothyronine (T3) and free triiodothyronine (FT3) in haemodialysis patients are a marker of malnutrition and inflammation and are predictors of mortality. Aim and objectives: The aim of this study is improving the quality of life and decreasing morbidity in hemodialysis patients by focusing on malnutrition-inflammation complex syndrome (MICS) and clarify the relationship between it and changes in serum thyroid hormones, Subjects and methods: this is a cross sectional study that was carried out at hemodialysis units of Zagazig university hospitals and Fakous general hospital, and the study was conducted on 91 patients with more than three months on HD, three sessions/ week, age between 18 and 69 years, and without known thyroid disease, all patients were referred for measurement of IL6.Level, Results: prevalence of MIC was 56% and there is high significant relation between MIC and albumin,IL-6 and transferrin, also there is significant relation between MIC
and cholesterol, while there is no significant relation between MIC and HB, TLC, glucose, TG, T3, T4 and TSH, Conclusion: MICS significantly correlated with BMI, duration of hemodialysis, SBP, DBP, serum creatinine, serum cholesterol, triglycerides, IL 6, transferrin and a negative correlation with serum albumin.