The aims of the research is to rate the effectiveness of giving curcumin 7 days before menstruation in order to decrease the pain Intensity of women with primary Dysmenorrhea. The research is using randomized controlled trial method analysis with block permutation to women with Primary dysmenorrhea. The statistic data then processed by using SPSS 21. The level of PGF2a on women that consume curcumin decreased significantly from 677.31 ± 387.27 became 419 ± 234.58 with the ratio P 0.001 compared to control group. The average scale of visual analogue scale (VAS) also decreased significantly to women that were given curcumin
supplementation which was from 5.33 ± 1.56 became 2.67 ± 1.15 with the ratio P 0.000. The research has shown that supplementation of curcumin has certain role in decreasing the pain Intensity and the prostaglandin F2a content to women with Primary dysmenorrhea.