The Efficiency of Resveratrol on Adenomatous Polyposis Coli Gene in Mice Colorectal Cancer Treated with Azoxymethane

Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death. Most cases of CRC are detected in Western countries, with its incidence increasing year by year. The probability of suffering from colorectal cancer is about 4%–5% and the risk for developing CRC is associated with personal features or habits such as age, chronic disease history and lifestyle. 5-Fluorouracil (5-FU) is the most commonly used therapy and the conventional treatment for colorectal cancer. However, its toxicity to normal tissues is considered a major obstacle to successful cancer chemotherapy; thus, resveratrol is used in combination with 5-FU to reduce its toxicity. The goal of our study is to investigate the mechanisms underlying the effects of resveratrol alone and in combination with 5-FU in inhibiting experimentally induced colon cancer. Gene expression analysis showed seemed lower expression of APC (adenomatus polyposis coli) gene in (+) control significantly difference between positive and negative control by given Azoxymethane and normal saline respectively, The mean expression levels of (-) control (n=6) and combination (Res. +5-FU) (n=6) mice in the colon, There are high statistically significant expression differences. Error bars represent the 95% confidence intervals.