Pathogenetic Value of Cytokine Production in HIV Infection

Against the background of the progression of HIV infection, there is an imbalance in the production of cytokines, characterized by the switching of the TV-1 response to TV-2. As the disease progresses, the prevalence of anti-inflammatory cytokines produced by Th-2 cells is observed, which shows the aggravation of immunosuppression and the development of opportunistic diseases. It was revealed that IL-2, IL-4 and IL-10 might have a multidirectional action depending on local conditions. Thus, cytokines can serve as markers for predicting the progression of HIV infection.