Synthesis of New Gemcitabine Derivatives Linked Tetrazole Ring as Antibacterial Activity

Authors

  • Ali Fattah Naser Al-Kafeel University, Najaf, Iraq Author
  • Ammar Kareem Madlool Imam Ja,afer Al-Sadiq University, Najaf, Iraq Author
  • Dheyaa Hussein Mohsin Ministry of Education, Najaf, Iraq Author
  • Ehab Kareem Obaid Faculty of Agriculture, Al-Qasim Green University, Babylon, Iraq Author
  • Ali Jabbar Radhi Al-Kafeel University, Najaf, Iraq Author

DOI:

https://doi.org/10.61841/f3g72p91

Keywords:

Antibacterial Activity, Gemcitabine, Tetrazole, Heterocyclic

Abstract

A series of novel tetrazole derivatives containing nucleoside analogs were synthesized by reaction between azido gemcitabine and nitrile compounds in the presence of ammonium chloride as a catalyst. The structures of all prepared compounds were analyzed by NMR and FTIR spectroscopic methods. The antibacterial activity of tetrazole derivatives was determined by using Streptococcus pneumoniae, Escherichia coli, and Staphylococcus aureus. 

Downloads

Download data is not yet available.

References

[1] W.S. Farked, J.T. Ahmed, A.S. Hayder, and J.R. Ali, Nano Biomed. Eng., 11(1), 84 (2019).

[2] K.K.Y. Cham, J.H.E. Baker, K.S. Takhar, J.A. Flexman, M.Q. Wong, D.A. Owen, A. Yung, P. Kozlowski, S.A. Reinsberg, E.M. Chu, C.W.A. Chang, A.K. Buczkowski, S.W. Chung, C.H. Scudamore, A.I. Minchinton, D.T.T. Yapp, and S.S.W. Ng, British Journal of Cancer, 103,5(2010).

[3] P. Vijay, N. Vanita, J. Amit, C. Anuradha, K. Sadhana, B. Atanu, G. Supriya, M. Sucheta, C. Arun, M. Nandini, S. Sujay, H. Dilip, D. Hollis, M. Swaratika, D. Sudeep, Z. Abhinav, K. Satvik, K. Amit, S. S.Gunjesh, A. Kanteti, R. Rahul, T. Vaishakhi, B. Vichitra, M. Abhishek, J. Amit, P. Nilendu, and P. Kumar, E Clinical Medicine, 9, 19 (2019).

[4] S.A. Saddoughi, E. Garrett-Mayer, U. Chaudhary, P.E. O'Brien, L.B. Afrin, T.A. Day, M.B. Gillespie, A.

K. Sharma, C. S. Wilhoit, R. Bostick, C. E. Senkal, Y.A. Hannun, J. Bielawski, G. R. Simon, K. Shirai and

B. Ogretmen, Clin Cancer Res., 17(18), 17(18),6097 (2011).

[5] R.L. Siegel, K.D. Millerand A. Jemal, CA Cancer J Clin. 67(1), 7(2017).

[6] J.R. Ali, H.Z. Ezzat, and A.J. Emad, Research J. Pharm. and Tech., 12(3), 1145 (2019).

[7] A.F. Abbass and E.H. Zimam, International Journal of ChemTech Research, 9, 206 (2016).

[8] R.J. Herr, Bioorg. Med. Chem., 10(11), 3379 (2002).

[9] K. K.Rama, Vishal, and A. Alka, Comptes Rendus Chimie., 19, (3), 306 (2016).

[10] A.R. Modarresi-Alam, H. Keykha, F. Khamooshi, and H.A. Dabbagh, Tetrahedron, 60, 1525 (2004).

[11] A.R. Modarresi-Alam, F. Khamooshi, M. Rostamizadeh, H. Keykha, M. Nasrollahzadeh, H. R. R.Bijanzadeh and E. J. Kleinpeter, Mol. Struct., 841, 61 (2007).

[12] I.V. Tselinskii, V. Tolstyakov, S.M. Putis, and S.F. Mel’nikova, Russian Chemical Bulletin, 58 (11), 2356 (2009).

[13] E. Naresh, K. Bhaskar, and G. Linga, Russian Journal of General Chemistry, 86 (12):2862 (2016).

[14] B.S. Jursic and B.W. Leblanc, J. Heterocycl. Chem., 35, 405 (1998).

[15] G. Madhu, G. Ravikumar, K. Raju, A. Raja, G. Hymavathi, S. Haritha, P. Hari, M. Padma, and B. R. Venkateswara, Der Pharma Chemica, 7(11), 268 (2015).

[16] K. Ferydoon and H.K.J. Batool , Industrial and Ecological Chemistry, 7 (2), 130 (2012).

[17] R.M. Ali and N. Mahmoud, Turk J Chem, 33, 33,267 (2009).

[18] L.C. Ajay and D. Alexander, Green Chem., 18(13), 3718 (2016).

[19] Z.Z. Yu, Z. Xinqi, and Y. Congxuan, Journal of Chemical Crystallography, 34(9), 597 (2004).

[20] B.P. Umakant, R.K. Kedar, and M.N. Jayashree, Tetrahedron Letters, 53, 3706 (2012).

[21] A. Gagnon, S. L. L.andry, R. Coulombe, A. Jakalian, I. Guse, B. Thavonekham, P.R. Bonneau, C. Yoakim, and B. Simoneau, Bioorg. Med. Chem., 19, 1199 (2009).

[22] K.O. Ehab, J.H. Najlaa, W.S. Farked, A.S. Hayder, and J.R. Ali, International Journal of Pharmaceutical Research, 11(2), 518 (2019).

Downloads

Published

31.07.2020

Issue

Vol. 24 No. 5 (2020): 24 (5) 2020

Section

Articles

License

Copyright (c) 2020 AUTHOR

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  2. Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .

No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

How to Cite

Fattah Naser, A., Kareem Madlool, A., Hussein Mohsin, D., Kareem Obaid, E., & Jabbar Radhi, A. (2020). Synthesis of New Gemcitabine Derivatives Linked Tetrazole Ring as Antibacterial Activity. International Journal of Psychosocial Rehabilitation, 24(5), 1806-1813. https://doi.org/10.61841/f3g72p91