Synthesis of New Gemcitabine Derivatives Linked Tetrazole Ring as Antibacterial Activity

Authors

  • Ali Fattah Naser Al-Kafeel University, Najaf, Iraq Author
  • Ammar Kareem Madlool Imam Ja,afer Al-Sadiq University, Najaf, Iraq Author
  • Dheyaa Hussein Mohsin Ministry of Education, Najaf, Iraq Author
  • Ehab Kareem Obaid Faculty of Agriculture, Al-Qasim Green University, Babylon, Iraq Author
  • Ali Jabbar Radhi Al-Kafeel University, Najaf, Iraq Author

DOI:

https://doi.org/10.61841/f3g72p91

Keywords:

Antibacterial Activity, Gemcitabine, Tetrazole, Heterocyclic

Abstract

A series of novel tetrazole derivatives containing nucleoside analogs were synthesized by reaction between azido gemcitabine and nitrile compounds in the presence of ammonium chloride as a catalyst. The structures of all prepared compounds were analyzed by NMR and FTIR spectroscopic methods. The antibacterial activity of tetrazole derivatives was determined by using Streptococcus pneumoniae, Escherichia coli, and Staphylococcus aureus. 

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References

[1] W.S. Farked, J.T. Ahmed, A.S. Hayder, and J.R. Ali, Nano Biomed. Eng., 11(1), 84 (2019).

[2] K.K.Y. Cham, J.H.E. Baker, K.S. Takhar, J.A. Flexman, M.Q. Wong, D.A. Owen, A. Yung, P. Kozlowski, S.A. Reinsberg, E.M. Chu, C.W.A. Chang, A.K. Buczkowski, S.W. Chung, C.H. Scudamore, A.I. Minchinton, D.T.T. Yapp, and S.S.W. Ng, British Journal of Cancer, 103,5(2010).

[3] P. Vijay, N. Vanita, J. Amit, C. Anuradha, K. Sadhana, B. Atanu, G. Supriya, M. Sucheta, C. Arun, M. Nandini, S. Sujay, H. Dilip, D. Hollis, M. Swaratika, D. Sudeep, Z. Abhinav, K. Satvik, K. Amit, S. S.Gunjesh, A. Kanteti, R. Rahul, T. Vaishakhi, B. Vichitra, M. Abhishek, J. Amit, P. Nilendu, and P. Kumar, E Clinical Medicine, 9, 19 (2019).

[4] S.A. Saddoughi, E. Garrett-Mayer, U. Chaudhary, P.E. O'Brien, L.B. Afrin, T.A. Day, M.B. Gillespie, A.

K. Sharma, C. S. Wilhoit, R. Bostick, C. E. Senkal, Y.A. Hannun, J. Bielawski, G. R. Simon, K. Shirai and

B. Ogretmen, Clin Cancer Res., 17(18), 17(18),6097 (2011).

[5] R.L. Siegel, K.D. Millerand A. Jemal, CA Cancer J Clin. 67(1), 7(2017).

[6] J.R. Ali, H.Z. Ezzat, and A.J. Emad, Research J. Pharm. and Tech., 12(3), 1145 (2019).

[7] A.F. Abbass and E.H. Zimam, International Journal of ChemTech Research, 9, 206 (2016).

[8] R.J. Herr, Bioorg. Med. Chem., 10(11), 3379 (2002).

[9] K. K.Rama, Vishal, and A. Alka, Comptes Rendus Chimie., 19, (3), 306 (2016).

[10] A.R. Modarresi-Alam, H. Keykha, F. Khamooshi, and H.A. Dabbagh, Tetrahedron, 60, 1525 (2004).

[11] A.R. Modarresi-Alam, F. Khamooshi, M. Rostamizadeh, H. Keykha, M. Nasrollahzadeh, H. R. R.Bijanzadeh and E. J. Kleinpeter, Mol. Struct., 841, 61 (2007).

[12] I.V. Tselinskii, V. Tolstyakov, S.M. Putis, and S.F. Mel’nikova, Russian Chemical Bulletin, 58 (11), 2356 (2009).

[13] E. Naresh, K. Bhaskar, and G. Linga, Russian Journal of General Chemistry, 86 (12):2862 (2016).

[14] B.S. Jursic and B.W. Leblanc, J. Heterocycl. Chem., 35, 405 (1998).

[15] G. Madhu, G. Ravikumar, K. Raju, A. Raja, G. Hymavathi, S. Haritha, P. Hari, M. Padma, and B. R. Venkateswara, Der Pharma Chemica, 7(11), 268 (2015).

[16] K. Ferydoon and H.K.J. Batool , Industrial and Ecological Chemistry, 7 (2), 130 (2012).

[17] R.M. Ali and N. Mahmoud, Turk J Chem, 33, 33,267 (2009).

[18] L.C. Ajay and D. Alexander, Green Chem., 18(13), 3718 (2016).

[19] Z.Z. Yu, Z. Xinqi, and Y. Congxuan, Journal of Chemical Crystallography, 34(9), 597 (2004).

[20] B.P. Umakant, R.K. Kedar, and M.N. Jayashree, Tetrahedron Letters, 53, 3706 (2012).

[21] A. Gagnon, S. L. L.andry, R. Coulombe, A. Jakalian, I. Guse, B. Thavonekham, P.R. Bonneau, C. Yoakim, and B. Simoneau, Bioorg. Med. Chem., 19, 1199 (2009).

[22] K.O. Ehab, J.H. Najlaa, W.S. Farked, A.S. Hayder, and J.R. Ali, International Journal of Pharmaceutical Research, 11(2), 518 (2019).

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Published

31.07.2020

How to Cite

Fattah Naser, A., Kareem Madlool, A., Hussein Mohsin, D., Kareem Obaid, E., & Jabbar Radhi, A. (2020). Synthesis of New Gemcitabine Derivatives Linked Tetrazole Ring as Antibacterial Activity. International Journal of Psychosocial Rehabilitation, 24(5), 1806-1813. https://doi.org/10.61841/f3g72p91