EUGENOL AS POTENTIAL MEDICINEREVIEW

Authors

  • Akshaya. R Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-77, India Author
  • Jayalakshmi somasundaram Chief Scientist, White lab - Material research centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-77, India Author
  • Anjali A.K. Lecturer, Department of General Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-77, India Author

DOI:

https://doi.org/10.61841/00hfzm12

Keywords:

Eugenol, Antibacterial agent, Clove oil, Dentistry, Antioxidants, Anaesthetics

Abstract

The aim of this study is to evaluate the abutment teeth selection in fixed partial denture (FPD) done by undergraduate students. For this, eugenol is a naturally occurring phenolic molecule that is used in dentistry. Eugenol is also used as a topical anesthetic agent in dentistry. Moreover, it has many pharmacological effects, like anesthetic and analgesic action in dentistry, and also antibacterial and antioxidant effects. Eugenol and thymol were found to possess general anesthetic properties. Since it is a phytochemical constituent, it exhibits highly potent anticancer activities that have been attributed to their effect on multiple signalling and apoptotic pathways. It illustrates potent antibacterial potential against the numerous strains of gram-positive and gram-negative bacteria. Eugenol damages the cell membrane and cell wall, which then induces cell lysis in gram-positive and gram-negative bacteria. It is also used as an irritant, sensitizer, flavoring agent, and root canal medicament in dentistry. Clove oil or eugenol can be used as a local anesthetic and also used as an anesthetic agent in several fish species. In this review study, an elaborate role of eugenol as a potential medicine is required. The review of the scientific literature was done in the preparation of the manuscript. The systems and databases were searched for relevant articles from PubMed and Google Scholar. Databases of individual journals were searched for keywords in this review. The aim of this study is to analyze the role of eugenol as potential medicine . The published article was selected from the years 1980 to 2020. In this review, 47 articles were reviewed. Hence, future research should be aimed at identifying different activities of eugenol. 

Downloads

Download data is not yet available.

References

1. Cho JS, Kim TH, Lim J-M, Song J-H. Effects of eugenol on Na+ currents in rat dorsal root ganglion

neurons. Brain Res. 2008 Dec 3;1243:53–62.

2. Khalil AA, Rahman U ur, Khan MR, Sahar A, Mehmood T, Khan M. Essential oil eugenol: sources,

extraction techniques and nutraceutical perspectives. RSC Adv. 2017;7(52):32669–81.

3. Pavithra B. Eugenol-a review. Res J Pharm Biol Chem Sci [Internet]. 2014; Available from:

https://core.ac.uk/download/pdf/24061559.pdf

4. Markowitz K, Moynihan M, Liu M. Biologic properties of eugenol and zinc oxide-eugenol: a clinically

oriented review. Oral surgery, oral medicine [Internet]. 1992; Available from:

https://www.oooojournal.net/article/0030-4220(92)90020-Q/fulltext

5. Woody TL, Davis RD. The effect of eugenol-containing and eugenol-free temporary cements on

microleakage in resin-bonded restorations. Oper Dent. 1992 Sep;17(5):175–80.

6. Lindqvist L, Otteskog P. Eugenol: liberation from dental materials and effect on human diploid fibroblast

cells. Scand J Dent Res. 1980 Dec;88(6):552–6.

7. Millstein PL, Nathanson D. Effect of eugenol and eugenol cements on cured composite resin. J Prosthet

Dent. 1983 Aug;50(2):211–5.

8. Roubach R, Gomes LC, Leao Fonseca FA, Val AL. Eugenol as an efficacious anaesthetic for tambaqui.

Colossoma macropomum (Cuvier). Aquac Res. 2005 Aug;36(11):1056–61.

9. Fujisawa S, Kashiwagi Y, Atsumi T, Iwakura I, Ueha T, Hibino Y, et al. Application of bis-eugenol to a

Zinc oxide eugenol cement. J Dent. 1999 May;27(4):291–5.

10. de Araújo Lopes A, da Fonseca FN, Rocha TM, de Freitas LB, Araújo EVO, Wong DVT, et al. Eugenol

as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities

and its nanoformulation. Oxid Med Cell Longev. 2018 Dec 11;2018:8194849.

11. Li HY, Park C-K, Jung SJ, Choi S-Y, Lee SJ, Park K, et al. Eugenol inhibits K+ currents in trigeminal

ganglion neurons. J Dent Res. 2007 Sep;86(9):898–902.

12. Park C-K, Kim K, Jung SJ, Kim MJ, Ahn DK, Hong S-D, et al. Molecular mechanism for local anesthetic

action of eugenol in the rat trigeminal system. Pain. 2009 Jul;144(1-2):84–94.

13. Ramamoorthi S, Nivedhitha MS, Divyanand MJ. Comparative evaluation of postoperative pain after using endodontic needle and EndoActivator during root canal irrigation: A randomized controlled trial. Aust

Endod J. 2015 Aug;41(2):78–87.

14. Ramanathan S, Solete P. Cone-beam Computed Tomography Evaluation of Root Canal Preparation using

Various Rotary Instruments: An in vitro Study. J Contemp Dent Pract. 2015 Nov 1;16(11):869–72.

15. Siddique R, Sureshbabu NM, Somasundaram J, Jacob B, Selvam D. Qualitative and quantitative analysis

of precipitate formation following interaction of chlorhexidine with sodium hypochlorite, neem, and tulsi.

J Conserv Dent. 2019 Jan;22(1):40–7.

16. Rajakeerthi R, Ms N. Natural Product as the Storage Medium for an avulsed tooth--A Systematic Review.

Cumhuriyet Dental Journal. 2019;22(2):249–56.

17. Rajendran R, Kunjusankaran RN, Sandhya R, Anilkumar A, Santhosh R, Patil SR. Comparative

Evaluation of Remineralizing Potential of a Paste Containing Bioactive Glass and a Topical Cream

Containing Casein Phosphopeptide-Amorphous Calcium Phosphate: An in Vitro Study. Pesqui Bras

Odontopediatria Clin Integr [Internet]. 2019;19. Available from:

http://www.scielo.br/scielo.php?pid=S1983-46322019000100364&script=sci_arttext

18. Hussainy SN, Nasim I, Thomas T, Ranjan M. Clinical performance of resin-modified glass ionomer

Cement, flowable composite, and polyacid-modified resin composite in noncarious cervical lesions: One-year follow-up. J Conserv Dent. 2018 Sep;21(5):510–5.

19. Kumar D, Antony S. Calcified Canal and Negotiation-A Review. Research Journal of Pharmacy and

Technology. 2018;11(8):3727–30.

20. Ravinthar K, Others. Recent Advancements in Laminates and Veneers in Dentistry. Research Journal of

Pharmacy and Technology. 2018;11(2):785–7.

21. Noor S, Others. Chlorhexidine: Its properties and effects. Research Journal of Pharmacy and Technology.

2016;9(10):1755–60.

22. Teja KV, Ramesh S, Priya V. Regulation of matrix metalloproteinase-3 gene expression in inflammation:

A molecular study. J Conserv Dent. 2018 Nov;21(6):592–6.

23. Janani K, Palanivelu A, Sandhya R. Diagnostic accuracy of dental pulse oximeter with customized sensor

holder, thermal test, and electric pulp test for the evaluation of pulp vitality: an in vivo study. Brazilian

Dental Science. 2020;23(1):8.

24. Jose J, Subbaiyan H. Different Treatment Modalities followed by Dental Practitioners for Ellis Class 2

Fracture—A Questionnaire-based Survey. Open Dent J [Internet]. 2020; Available from:

https://opendentistryjournal.com/VOLUME/14/PAGE/59/FULLTEXT/

25. Teja KV, Ramesh S. Shape optimally and clean more. Saudi Endodontic Journal [Internet]. 2019; Available

from: http://www.saudiendodj.com/article.asp?issn=1658-

5984;year=2019;volume=9;issue=3;spage=235;epage=236;aulast=Teja

26. Manohar MP, Sharma S. A survey of the knowledge, attitude, and awareness about the principal choice of

intracanal medicaments among the general dental practitioners and … Indian J Dent Res [Internet]. 2018;

Available from: http://www.ijdr.in/article.asp?issn=0970-

9290;year=2018;volume=29;issue=6;spage=716;epage=720;aulast=Manohar

27. Mahalakshmi Nandakumar In a comparative evaluation of grape seed and cranberry extracts in preventing

Enamel erosion: An optical emission spectrometric analysis. J Conserv Dent [Internet]. 2018; Available

from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161533/

28. Lee MH, Yeon K-Y, Park C-K, Li H-Y, Fang Z, Kim MS, et al. Eugenol inhibits calcium currents in dental afferent neurons. J Dent Res. 2005 Sep;84(9):848–51.

29. Javahery S, Nekoubin H, Moradlu AH. Effect of anesthesia with clove oil in fish (review). Fish Physiol

Biochem. 2012 Dec;38(6):1545–52.

30. Gülçin İ. Antioxidant Activity of Eugenol: A Structure–Activity Relationship Study. J Med Food. 2011

Sep 1;14(9):975–85.

31. Chaieb KH, Hajlaoui T, Zmantar KAB, Nakbi M, Rouabhia K, Mahdouani, and Bakhrouf A. 2007. The

chemical composition and biological activity of essential oil, Eugenia cryophyllata

(Syzygium aromaticum L. Myrtaceae). Phytotherapy Research Wiley Int Sci. 21(6):501–6.

32. Romaneli R de S, Boaratti AZ, Rodrigues AT, Queiroz DM de A, Khan KU, Nascimento TMT, et al.

Efficacy of Benzocaine, Eugenol, and Menthol as Anesthetics for Freshwater Angelfish. J Aquat Anim

Health. 2018 Sep;30(3):210–6.

33. Shan B, Cai Y-Z, Brooks JD, Corke H. The in vitro antibacterial activity of dietary spice and medicinal

herb extracts. Int J Food Microbiol. 2007 Jun 10;117(1):112–9.

34. Hemaiswarya S, Doble M. Synergistic interaction of eugenol with antibiotics against Gram-negative

bacteria. Phytomedicine. 2009 Nov;16(11):997–1005.

35. Khalilzadeh E, Hazrati R, Saiah GV. Effects of topical and systemic administration of Eugenia

caryophyllata buds essential oil on corneal anesthesia and analgesia. Res Pharm Sci. 2016 Jul;11(4):293–

302.

36. Pramod K, Ansari SH, Ali J. Eugenol: a natural compound with versatile pharmacological actions. Nat

Prod Commun. 2010 Dec;5(12):1999–2006.

37. Prakash P, Gupta N. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its

Pharmacological actions: a short review. Indian J Physiol Pharmacol. 2005 Apr;49(2):125–31.

38. Rajeshwari S. Ocimum sanctum. The Indian home remedy. Current Medical Scene March-April

(published by Cipla Ltd., Bombay Central, Bombay). 1992;

39. Hassan HA, Geniady MM, Abdelwahab SF, Abd-Elghany MI, Sarhan HA, Abdelghany AA, et al. Topical

Eugenol Successfully Treats Experimental Candida albicans-Induced Keratitis. Ophthalmic Res. 2018 Jul

3;60(2):69–79.

40. Jaganathan SK, Mazumdar A, Mondhe D, Mandal M. Apoptotic effect of eugenol in human colon cancer

cell lines. Cell Biol Int. 2011 Jun;35(6):607–15.

41. Ali SM, Khan AA, Ahmed I, Musaddiq M, Ahmed KS, Polasa H, et al. Antimicrobial activities of

Eugenol and cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Ann Clin

Microbiol Antimicrob. 2005 Dec 21;4:20.

42. Park C-K, Li HY, Yeon K-Y, Jung SJ, Choi S-Y, Lee SJ, et al. Eugenol inhibits sodium currents in dental

afferent neurons. J Dent Res. 2006 Oct;85(10):900–4.

43. Robin O, Alaoui-Ismaïli O, Dittmar A, Vernet-Maury E. Basic emotions evoked by eugenol odor differ

according to the dental experience. A neurovegetative analysis. Chem Senses. 1999 Jun;24(3):327–35.

44. Brännström M, Nyborg H. Pulp reaction to a temporary zinc oxide/eugenol cement. J Prosthet Dent. 1976

Feb;35(2):185–91.

45. Sarrami N, Pemberton MN, Thornhill MH, Theaker ED. Adverse reactions associated with the use of eugenol in dentistry. Br Dent J. 2002 Sep 14;193(5):257–9.

46. Jeng JH, Hahn LJ, Lu EJ, Wang YJ, Kuo MYP. Eugenol Triggers Different Pathobiological Effects on Human Oral Mucosal Fibroblasts 1. J Dent Res. 1994 May 1;73(5):1050–5.

47. Markakis C, Tsaroucha A, Papalois AE, Lambropoulou M, Spartalis E, Tsigalou C, et al. The Role of Eugenol in the Prevention of Acute Pancreatitis-Induced Acute Kidney Injury: Experimental Study. HPB Surg. 2016 Jan 17;2016:3203147.

Downloads

Published

31.05.2020

How to Cite

R, A., somasundaram, J., & A.K., A. (2020). EUGENOL AS POTENTIAL MEDICINEREVIEW. International Journal of Psychosocial Rehabilitation, 24(3), 5167-5173. https://doi.org/10.61841/00hfzm12