Awareness of tumor suppressor genes among dental students
DOI:
https://doi.org/10.61841/xccxd093Keywords:
Awareness, Tumour suppressor genes, Dental students, CancerAbstract
Tumor formation arises as a consequence of alterations in the control of cell proliferation and disorders in the interactions between cells and their surroundings that result in invasion and metastasis. Tumor suppressor genes activate a multitude of genes encoding proteins with functions in cell-cycle control, DNA repair, senescence, and apoptosis. The present study aims to find the awareness of tumor suppressor genes among dental students. An online questionnaire was formulated and distributed among 215 dental students in Saveetha Dental College, Chennai, pursuing undergraduate and postgraduate courses. Of 215 students, 200 students responded. A total of 10 multiple-choice questions were formulated and distributed. Data were collected from the filled questionnaire and analysed. Descriptive statistics were done using SPSS statistical analysis. The results of the present study findings show that there was no significant association between undergraduate and postgraduate dental students on awareness of tumour suppressor genes (p = 0.174). The overall awareness level of tumour suppressor genes among dental students was moderate. This study showed that the awareness of tumor suppressor genes was moderate among the dental students. Increased importance should be given to education in this aspect of tumor suppressor genes.
Downloads
References
1. Adams PD and Kaelin WG Jr. (1998) Negative control elements of the cell cycle in human tumors. Current opinion in cell biology 10(6): 791–797.
2. Anbu RT, Suresh V, Gounder R, et al. (2019) Comparison of the Efficacy of Three Different Bone Regeneration Materials: An Animal Study. European journal of dentistry 13(1): 22–28.
3. Ariga P, Nallaswamy D, Jain AR, et al. (2018) Determination of Correlation of Width of Maxillary Anterior Teeth using Extraoral and Intraoral Factors in Indian Population: A Systematic Review. World Journal of Dentistry 9(1): 68–75.
4. Ashok V and Ganapathy D (2019) A geometrical method to classify face forms. Journal of oral biology and craniofacial research 9(3): 232–235.
5. Brennan JA, Boyle JO, Koch WM, et al. (1995) Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. The New England journal of medicine 332(11): 712–717.
6. Chang F, Syrjänen S, and Syrjänen K (1995) Implications of the p53 tumor suppressor gene in clinical oncology. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 13(4): 1009–1022.
7. Di Cristofano A, Pesce B, Cordon-Cardo C, et al. (1998) PTEN is essential for embryonic development and tumour suppression. Nature genetics 19(4): 348–355.
8. Döhner H, Fischer K, Bentz M, et al. (1995) p53 gene deletion predicts poor survival and nonresponse to therapy with purine analogs in chronic B-cell leukemias. Blood 85(6): 1580–1589.
9. Duraisamy R, Krishnan CS, Ramasubramanian H, et al. (2019). Compatibility of Nonoriginal Abutments With Implants: Evaluation of Microgap at the Implant-Abutment Interface, With Original and Nonoriginal Abutments. Implant dentistry 28(3): 289–295.
10. Ganapathy DM, Kannan A, and Venugopalan S (2017) Effect of Coated Surfaces influencing Screw Loosening in Implants: A Systematic Review and Meta-analysis. World Journal of Dentistry 8(6):496–502.
11. Goodrich DW (2006) The retinoblastoma tumor suppressor gene, the exception that proves the rule. Oncogene 25(38): 5233–5243.
12. Gupta P, Ariga P, and Deogade SC (2018) Effect of Monopoly-Coating Agent on the Surface Roughness of a Tissue Conditioner Subjected to Cleansing and Disinfection: A Contact Profilometric Study. Contemporary clinical dentistry 9(Suppl 1): S122–S126.
13. Jain AR (2017a) Clinical and Functional Outcomes of Implant Prostheses in Fibula-Free Flaps. World Journal of Dentistry 8(3): 171–176.
14. Jain AR (2017b) Prevalence of Partial Edentulousness and Treatment Needs in Rural Population of South India. World Journal of Dentistry 8(3): 213–217.
15. Kersh EN and Fitzpatrick DR (2006) Rapid demethylation of the IFN-γ gene occurs in memory but not naive CD8 T cells. The Journal of. Am Assoc Immnol. Available at:https://www.jimmunol.org/content/176/7/4083.short.
16. Lambertini M, Goldrat O, Toss A, et al. (2017) Fertility and pregnancy issues in BRCA-mutated breast cancer patients. Cancer treatment reviews 59: 61–70.
17. Lipsick J. (2020). A History of Cancer Research: Tumor Suppressor Genes. Cold Spring Harbor Perspectives in Biology. DOI: 10.1101/cshperspect.a035907.
18. McClatchey AI, Saotome I, Ramesh V, et al. (1997) The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes & Development 11(10): 1253–1265.
19. Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266(5182): 66–71.
20. Nielsen LL and Maneval DC (1998) P53 tumor suppressor gene therapy for cancer. Cancer gene therapy 5(1): 52–63.
21. Nkondjock A and Ghadirian P (2004) Epidemiology of breast cancer among BRCA mutation carriers: an overview. Cancer letters 205(1): 1–8.
22. Ranganathan H, Ganapathy DM, and Jain AR (2017) Cervical and Incisal Marginal Discrepancy in Ceramic Laminate Veneering Materials: A SEM Analysis. Contemporary clinical dentistry 8(2): 272-278.
23. Rebbeck TR, Mitra N, Wan F, et al. (2015) Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. JAMA: the journal of the American Medical Association 313(13): 1347–1361.
24. Rubinfeld B, Souza B, Albert I, et al. (1993) Association of the APC gene product with beta-catenin. Science 262(5140): 1731–1734.
25. Sakai T, Toguchida J, Ohtani N, et al. (1991) Allele-specific hypermethylation of the retinoblastoma tumor suppressor gene. American journal of human genetics 48(5): 880–888.
26. Sauerbrey A, Stammler G, Zintl F, et al. (1998) Expression of the retinoblastoma tumor suppressor gene (RB-1) in acute leukemia. Leukemia & lymphoma 28(3-4): 275–283.
27. Varghese SS, Ramesh A, and Veeraiyan DN (2019). Blended Module-Based Teaching in Biostatistics and Research Methodology: A Retrospective Study with Postgraduate Dental Students. Journal of dental education 83(4): 445–450.
28. Varley JM, Evans DG, and Birch JM (1997) Li-Fraumeni syndrome—a molecular and clinical review. British journal of cancer 76(1): 1–14.
29. Vogelstein B and Kinzler KW (1992) p53 function and dysfunction. Cell 70(4): 523–526.
30. World Journal of Dentistry (2017) Evaluation of Corrosive Behavior of Four Nickel-chromium Alloys in Artificial Saliva by Cyclic Polarization Test: An in vitro Study. 8(6): 477–482.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 AUTHOR
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
