(Chitosan-Iodine) Bio-Films and Its Applications
DOI:
https://doi.org/10.61841/2fqdqv82Keywords:
Chitosan, Wound healings, flamazine cream, Iodine, Inhibitiondiameter zoneAbstract
Films manufactured from chitosan polymer and iodine (I2) for treating wounds, infected, and burned areas. Chitosan-iodine composites are prepared by adding 14 wt.% iodine element to the chitosan matrix. As a solution and film (coating and composite) states are used to investigate their healing actions. Evaluating healing action is done by applying these solutions and films to the injured rabbits and comparing them with the flamazine cream treatment medical ointment. The antibacterial activity was checked in Hilla General Teaching Hospital by exposing the prepared samples to the action of Staphylococcus aureus (gram-positive), Escherichia coli (gram-negative), and Pseudomonas aeruginosa (gram-negative) microorganisms. The agar-well diffusion method was used to evaluate the antibacterial action by measuring the inhibition zone area. Results showed that the prepared composite film is the best, having diameter zones 45, 35, and 15 mm of antibacterial ability against Staphylococcus aureus, Escherichia coli, and Pseudomonas microorganisms, respectively. Density and wettability of chitosan film increased with the addition of I2, and the wettability of composite film as a function of time is greater than that of the pure and coating films. Also, the weight loss results proved that the losses of iodine in coated film (5.4%) are higher than in composite film (2.6%). Glass transition temperature (Tg) results proved the presence of physical interactions between chitosan and I2. The calculations of Tg values show that iodine gives energy to the chitosan film, to the composite film (11.69 kJ mol-1) and to the coated film (0.95 kJ mol-1). Complete healing of wound rabbits is obtained within seven days compared with the negative control (without treatment). Both types of films (coating and composite) show good healing power compared with present medical ointment, but composite film was better. The test is carried on to show the limited ability for area healing power of chitosan, iodine, chitosan-I2-coated, and composite films. Also, tests are carried out to join the films with the affected area, i.e., to create a new skin.
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References
1. Agull E., Rodrguez MS, Ramos V., Albertengo L., Present and future role of chitin and chitosan in food, Macromolecular Bioscience, 3(10), 521–530, 2003.
2. Jeon YJ, Kamil JY Shahidi F., Chitosan as an edible invisible film for quality preservation of herring and Atlantic cod, J AgricFood Chem, 50, 5167–5178, 2002.
3. Park SY, Marsh KS, Rhim JW, Characteristics of different molecular weight chitosan films, affected by the type of organic solvents, J Food Science, 67(1), 194–197, 2002.
4. Chillo S., Flores S., Mastromatteo M., Conte A., Gerschenson L., Del Nobile MA, Influence of glycerol and chitosan on tapioca starch-based edible film properties, J Food Eng, 88, 159–168, 2008.
5. Mirna FC, Jyrki H., Karin K., Anna CJ, Milja K., and Antonio IC, Solid-state and mechanical properties of aqueous chitosan-amylose starch films plasticized with polyols, AAPS PharmSciTech, 5(1), 1–6, 2004.
6. Suyatma NE, Tighzert L., Copinet A., Effects of hydrophilic plasticizer on mechanical, thermal, and surface properties of chitosan films, J Agric Food Chem, 53(10), 3950–3957, 2005.
7. Frithjof CK, Martin CF, Michael BZ, Lucy JC, George WL, History of Iodine Chemistry, 50, 11598–11600, 2011.
8. Chandar B., Ramasamy MK, Evaluation of Antioxidant and Antibacterial Activity of Ethanolic Extract in the Leaves of Combretum Albidum and Gas Chromatography-Mass Septrometry Analysis, Asian Journal of Pharmaceutical and Clinical, Vol. 9, Issue 4, 2017.
9. Santram L., Gautam PV, Relevance and Perspectives Of Experimental Wound Models In Wound Healing Research, Asian Journal of Pharmaceutical and Clinical, Vol. 10, Issue 7, 2017.
10. Dhivya S., Padma V., Santhini E., Wound dressings: a review, 5, 24, 2015.
11. Dodson CD, Dyer LA, Searcy J., Wright Z., Letourneau DK, Cenocladamide, adiydropyridone alkaloid from piper. Cenocladum. Phytochemistry, pp. 51-54, 2000.
12. KinlochAJ, Adhesion and Adhesives, Champman & Hall, New York, 1987.
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