DIETARY CAPSAICIN AND IMMUNE SYSTEM
DOI:
https://doi.org/10.61841/v0te4y86Keywords:
dietary capsaicin, immune system, chilli peppers, health benefits, organ junction, chemopreventive functionAbstract
Capsaicin is a chemical compound that was initially isolated from chili peppers in crystalline form. It was discovered that capsaicin caused a burning sensation in the mucous membranes of the oral cavity and the gastrointestinal tract. In addition, it increases the secretion of gastric acid and stimulates the nerve endings in the skinHot foods, such as peppers and sauces, contain an ingredient called capsaicin. Capsaicin can be a very effective pain reliever and is even used topically for neuropathy pain. Hot peppers can boost your immune system, helping to ward off germs that can cause illness. Capsaicin is an active component of immune System modulation and is an essential component of chilli peppers. They have also shown beneficial properties on organs in maintaining their health and condition Studies on capsaicin's and chilli peppers efficacy in modulating the immune system, its anti-inflammatory properties, maintaining organ health, and anti - carcinogen effects are collected and analysed. Besides having anticarcinogenic properties and killing tumor cells, capsaicin has been identified to have immune-modulating properties, being able to activate DCs through vanilloid receptor 1 (VR1). Previous studies showing its role in immunity, immune responses, and reducing insulin spikes in diabetes are focused on. The mechanism of action of capsaicin on the human immune system discussed . The study concludes by providing knowledge regarding the potential of capsaicin and its sale as a potent immune booster.
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1. Shieh S, Berke T. Capsicum, chillies, paprika, bird’s eye chilli [Internet]. Handbook of Herbs and Spices. 2001. Available from: http://dx.doi.org/10.1201/9781439823002.ch8
2. Berke TG, Shieh SC. Capsicum, chillies, paprika, bird’s eye chilli [Internet]. Handbook of Herbs and Spices. 2001. p. 111–22. Available from: http://dx.doi.org/10.1533/9781855736450.111
3. Sullivan KM, Bramlage WJ. Chilling Injury of Chile Peppers (Capsicum annuum L.) [Internet]. Vol. 35, HortScience. 2000. p. 829B – 829. Available from: http://dx.doi.org/10.21273/hortsci.35.5.829b
4. Derivative of chilli peppers could help muscle pain [Internet]. Vol. 18, Nursing Standard. 2004. p. 10–10. Available from: http://dx.doi.org/10.7748/ns.18.39.10.s27
5. Website [Internet]. [cited 2020 Jun 11]. Available from: https://www.scopus.com/record/display.uri?origin=recordpage&eid=2-s2.0- 84989287584
6. Website [Internet]. [cited 2020 Jun 11].Availablefrom: https://www.scopus.com/record/display.uri?origin=recordpage&eid=2-s2.0- 84944874047
7. Andrews J. Chilli Peppers [Internet]. The Cambridge World History of Food. 2000. p. 281–8. Available from: http://dx.doi.org/10.1017/chol9780521402149.030
8. Liu TC. Cell metabolism: Chilli peppers have their benefits [Internet]. Nature China. 2010. Available from: http://dx.doi.org/10.1038/nchina.2010.96
9. Ram RC, Sinha A. Microbial Diversity: Modern Trends. Daya Books; 2007. 313 p.
10. Mozsik G, Takeuchi K, Salam OA-. Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract: from Bench to Bedside. BoD – Books on Demand; 2014. 380 p.
11. Preethikaa S, Brundha MP. Awareness of diabetes mellitus among general population [Internet]. Vol. 11, Research Journal of Pharmacy and Technology. 2018. p. 1825. Available from:http://dx.doi.org/10.5958/0974-360x.2018.00339.6
12. Tanrıkulu-Küçük S, Başaran-Küçükgergin C, Söğüt İ, Tunçdemir M, Doğru-Abbasoğlu S, Seyithanoğlu M, et al. Dietary curcumin and capsaicin: Relationship with hepatic oxidative stress and apoptosis in rats fed a high fat diet. Adv Clin Exp Med. 2019 Aug;28(8):1013–20.
13. Mp B, Brundha MP, Nallaswamy D. Hide and seek in pathology- A research on game-based histopathology learning [Internet]. Vol. 10, International Journal of Research in Pharmaceutical Sciences. 2019. p. 1410–4. Available from: http://dx.doi.org/10.26452/ijrps.v10i2.606
14. John DA, Brundha MP. Awareness of Vitamin A Deficiency among Middle Aged Men-Research [Internet]. Vol. 05, Vitamins & Minerals. 2016. Available from: http://dx.doi.org/10.4172/2376-1318.1000144
15. Swetha S, Brundha MP. Analysis of knowledge about the hospital warning symbols among the postgraduate dental students-A comparative study [Internet]. Vol. 10, Research Journal of Pharmacy and Technology. 2017. p. 975. Available from: http://dx.doi.org/10.5958/0974-360x.2017.00177.9
16. Saleh BK, Omer A, Teweldemedhin B. Medicinal uses and health benefits of chili pepper (Capsicum spp.): a review [Internet]. Vol. 6, MOJ Food Processing & Technology. 2018. Available from: http://dx.doi.org/10.15406/mojfpt.2018.06.00183
17. Olatunji TL, Afolayan AJ. The suitability of chili pepper (Capsicum annuum L.) for alleviating human micronutrient dietary deficiencies: A review [Internet]. Vol. 6, Food Science & Nutrition. 2018. p. 2239–51. Available from: http://dx.doi.org/10.1002/fsn3.790
18. Palevitch D, Craker LE. Nutritional and Medical Importance of Red Pepper (Capsicum spp.) [Internet]. Vol. 3, Journal of Herbs, Spices & Medicinal Plants. 1996. p. 55–83. Available from:http://dx.doi.org/10.1300/j044v03n02_08
19. Brundha MP, Pathmashri VP, Sundari S. Quantitative Changes of Red Blood cells in Cancer Patients under Palliative Radiotherapy-A Retrospective Study [Internet]. Vol. 12, Research Journal of Pharmacy and Technology. 2019. p. 687. Available from: http://dx.doi.org/10.5958/0974-360x.2019.00122.7
20. Cronin JR. The Chili Pepper’s Pungent Principle: Capsaicin Delivers Diverse Health Benefits [Internet]. Vol. 8, Alternative and Complementary Therapies. 2002. p. 110–3. Available from:http://dx.doi.org/10.1089/10762800252909865
21. Bhattacharya A, Chattopadhyay A, Mazumdar D, Chakravarty A, Pal S. Antioxidant Constituents and Enzyme Activities in Chilli Peppers [Internet]. Vol. 16, International Journal of Vegetable Science. 2010. p. 201–11. Available from: http://dx.doi.org/10.1080/19315260903529709
22. Brundha MP, Saivignesh S. Myeloid sarcoma [Internet]. Vol. 3, International Journal of Clinicopathological Correlation. 2019. p. 41. Available from: http://dx.doi.org/10.4103/ijcpc.ijcpc_11_19
23. Brundha MP, Visha MG. A review on ankylosing spondylitis [Internet]. Vol. 3, International Journal of Clinicopathological Correlation. 2019. p. 44. Available from: http://dx.doi.org/10.4103/ijcpc.ijcpc_12_19
24. Singletary K. Red Pepper [Internet]. Vol. 46, Nutrition Today. 2011. p. 33–47. Available from: http://dx.doi.org/10.1097/nt.0b013e3182076ff2
25. Westerterp-Plantenga M, Pilou L H. Red Pepper Can Enhance Energy Metabolism and Satiety [Internet]. Vol. 49, Nutrition Today. 2014. p. S6–7. Available from:http://dx.doi.org/10.1097/01.nt.0000453845.91592.11
26. Yang D, Luo Z, Ma S, Wong WT, Ma L, Zhong J, et al. Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension [Internet]. Vol. 12, Cell Metabolism. 2010. p. 130–41. Available from: http://dx.doi.org/10.1016/j.cmet.2010.05.015
27. Deng Y, Huang X, Wu H, Zhao M, Lu Q, Israeli E, et al. Some like it hot: The emerging role of spicy food (capsaicin) in autoimmune diseases. Autoimmun Rev. 2016 May;15(5):451–6.
28. Sun F, Xiong S, Zhu Z. Dietary Capsaicin Protects Cardiometabolic Organs from Dysfunction [Internet]. Vol. 8, Nutrients. 2016. p. 174. Available from: http://dx.doi.org/10.3390/nu8050174
29. Szallasi A. Vanilloid (capsaicin) receptors in health and disease. Am J Clin Pathol. 2002 Jul;118(1):110–21.
30. Shreya, S., & Brundha, M. P. (2017). Alteration of haemoglobin value in relation to age, sex and dental diseases- a retrospective correlation study. Research Journal of Pharmacy and Technology, 10(5), 1363–1366. https://doi.org/10.5958/0974-360X.2017.00241.4
31. Kumar MDA, Ashok Kumar MD, Brundha MP. Awareness about nocturia-A questionnaire survey [Internet]. Vol. 9, Research Journal of Pharmacy and Technology. 2016. p. 1707. Available from: http://dx.doi.org/10.5958/0974-360x.2016.00344.9
32. Kalaiselvi, R., & Brundha, M. P. (2016). Prevalence of hysterectomy in south Indian population. Research Journal of Pharmacy and Technology, 9(11). https://doi.org/10.5958/0974-360X.2016.00398.X
33. Website [Internet]. [cited 2020 Jun 11]. Available from: https://www.scopus.com/record/display.uri?origin=recordpage&eid=2-s2.0- 84984998171
34. Hannah, R., Ramani, P., Brundha, M. P., Sherlin, H. J., Ranjith, G., Ramasubramanian, A., … Archana, S. (2019). Liquid paraffin as a rehydrant for air dried buccal smear. Research Journal of Pharmacy and Technology, 12(3), 1197–1200. https://doi.org/10.5958/0974-360X.2019.00199.9
35. Timothy, C. N., Samyuktha, P. S., & Brundha, M. P. (2019, August 1). Dental pulp stem cells in regenerative medicine – A literature review. Research Journal of Pharmacy and Technology. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360X.2019.00698.X
36. Surh YJ, Lee SS. Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Food Chem Toxicol. 1996 Mar;34(3):313–6.
37. Prashaanthi, N., & Brundha, M. P. (2018). A comparative study between popplet notes and conventional notes for learning pathology. Research Journal of Pharmacy and Technology, 11(1), 175–178. https://doi.org/10.5958/0974-360X.2018.00032.X
38. Patcharatrakul T, Gonlachanvit S. Chili Peppers, Curcumins, and Prebiotics in Gastrointestinal Health and Disease [Internet]. Vol. 18, Current Gastroenterology Reports. 2016. Available from: http://dx.doi.org/10.1007/s11894-016-0494-0
39. Pramanik KC, Srivastava SK. Role of Capsaicin in Cancer Prevention [Internet]. Role of Capsaicin in Oxidative Stress and Cancer. 2013. p. 1–18. Available from: http://dx.doi.org/10.1007/978-94-007-6317-
3_1
40. Erin N. Role of sensory neurons, neuroimmune pathways, and transient receptor potential vanilloid 1
(TRPV1) channels in a murine model of breast cancer metastasis. Cancer Immunol Immunother. 2020
Feb;69(2):307–14.
41. Prasad KN, Cole WC. Cancer and Nutrition. IOS Press; 1998. 251 p.
42. Lu M, Chen C, Lan Y, Xiao J, Li R, Huang J, et al. Capsaicin-the major bioactive ingredient of chili
peppers: bio-efficacy and delivery systems. Food Funct. 2020 Apr 30;11(4):2848–60.
43. Website [Internet]. [cited 2020 Jun 11]. Available from: https://www.scopus.com/record/display.
uri?origin=recordpage&eid=2-s2.0- 84989348627
44. Du Y, Lv Y, Zha W, Hong X, Luo Q. Chili Consumption and Risk of Gastric Cancer: A Meta-Analysis.
Nutr Cancer. 2020 Apr 2;1–10.
45. Sastry SK, Mandal B, Sano T, Hammond J. Capsicum annuum and Capsicum frutescens (Bell pepper,
Chilli, Pepper, Sweet pepper) [Internet]. Encyclopedia of Plant Viruses and Viroids. 2019. p. 372–431.
Available from: http://dx.doi.org/10.1007/978-81-322-3912-3_174
46. Perla V, Nadimi M, Reddy R, Hankins GR, Nimmakayala P, Harris RT, et al. Effect of ghost pepper on
cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma
cells. PLoS One. 2018 Oct 31;13(10):e0206183.
47. Shenoy PB, Brundha MP. Awareness of polycystic ovarian disease among females of age group 18-30
years. Res J Pharm Biol Chem Sci. 2016;8(8):813.
48. Balaji S, Brundha MP, Path DNB. Awareness of About Breast Cancer among Dental Surgeons. Res J
Pharm Biol Chem Sci. 2016;8(8):797.
49. P Jannathulferdioz BM. Awareness of Stye. Int J Pharm Sci Rev Res,. 40(1):30–2.
50. Brundha MP. A Comparative Study-The Role of Skin and Nerve Biopsy in Hansen’s Disease. Res J
Pharm Biol Chem Sci [Internet]. 2015; Available from:
https://www.researchgate.net/profile/Brundha_Mp/publication/283561218_A_comparative_study-
_the_role_of_skin_and_nerve_biopsy_in_hansen’s_disease/links/5892ba5d458515aeac946451/Acomparative-study-the-role-of-skin-and-nerve-biopsy-in-hansens-disease.pdf
51. Ravichandran H, Brundha MP. Awareness about personal protective equipments in hospital workers (sweepers and cleaners). International Journal of Pharmaceutical Sciences Review and Research. 2016;40(1):28–9.
52. Farhat Yaasmeen Sadique Basha, Rajeshkumar S, Lakshmi T, Anti-inflammatory activity of Myristica fragrans extract . Int. J. Res. Pharm. Sci., 2019 ;10(4), 3118-3120 DOI: https://doi.org/10.26452/ijrps.v10i4.1607
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