Correlation between vascular endothelial growth factor expression and cervical lymph node carcinoma
DOI:
https://doi.org/10.61841/nxv90c54Keywords:
Cervical lymph node, growth factor expression, nasopharyngeal carcinoma, vascular endothelialAbstract
Introduction, Recent experimental evidence indicates that angiogenesis affects tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is considered to be an important regulator of tumor angiogenesis. The present study was designed to examine the role of VEGF on cervical lymph node metastasis in primary nasopharyngeal carcinomas (NPCs). Methods: Formalin-fixed paraffin-embedded biopsy specimens were obtained from 36 primary NPC with histologically undifferentiated carcinomas and clinically divided into four cervical lymph node status, i.e. N0, N1, N2 and N3. The expression of VEGF was observed with immunohistochemistry involving rabbit polyclonal antibody Anti-Human VEGF-A (Biocare Medical, LLC, USA). Assessment of the staining was performed by two independent observers who had no knowledge of the clinical background of the patients. Mann-Whitney U test was used to determine the correlation between the expression of VEGF and cervical lymph node status. Statistical significance was defined as p < 0.05.Results: VEGF expression in NPC based on cervical lymph node status for weak VEGF expression was 83.33% for all samples, followed by moderate VEGF expression with16.67%. From the Mann-Whitney U-test result, it was found that p was 0.058. There was no significant correlation between VEGF expression and cervical lymph node status (p > 0.05). Conclusion: There was no correlation between the increase of VEGF expression and cervical lymph node enlargement in nasopharyngeal carcinoma.
Downloads
References
[1] Kentjono WA. Karsinoma nasofaring: etiologi, gejala, diagnosis, deteksi dini, terapi dan pencegahan. . Dalam (Kentjono WA, ed. Pelatihan deteksi dini kanker nasofaring untuk dokter umum di puskesmas, . 2010:hal 13-41).
[2] Adham M KA, Muhtadi AI, Roezin A, Hermani B, Gondhowiardjo S, et al. Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. . Journal of cancer research and therapeutics. 2012. :185-96.
[3] Wakisaka N WQ, Yoshizaki T, Furukawa M, Kawahara M, Nakanishi I, et al. Association of vascular endhothelial growth factor expression with angiogenesis and lymph node metastasis in nasopharyngeal carcinoma. . In: The Laryngoscope, 1999, no. 109, pp. 810-4.
[4] Li YH, Hu CF, Shao Q, Huang MY, Hou JH, Xie D, et al. Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma. Journal of translational medicine. 2008;6:1.
[5] Mulyarjo. Diagnosis dan penatalaksanaan karsinoma nasofaring. Dalam (Mulyarjo, Soedjak, S., Wisnubroto, Harmadji, S., Hasanusi, R., Artono, ed.). Naskah Lengkap Pendidikan Kedokteran Berkelanjutan III Ilmu Kesehatan THT-KL, hal 38-48.
[6] Widiastuti. Ekspresi protein BCL-2, CD-44, COX-2, dan VEGF pada karsinoma nasofaring respon tinggi dan respon rendah pasca radioterapi. [dalam: Disertasi]. Surabaya: Universitas Airlangga; 2010. .
[7] Sukardja IDG. Onkologi Klinik. . Surabaya: Airlangga University Press, 2000. .
[8] Zeng MS. Pathogenesis and etiology of nasopharyngeal carcinoma. Nasopharyngeal Cancer Multidisciplinary Management, Berlin: Springer, . 2010. :p.12-20.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 AUTHOR
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
