Effect of Dual-Task Net Step Exercise on Working Memory, Global Cognitive Function and Brain Derived Neurotrophic Factor Serum Levels in Elderly with Mild and Moderate Cognitive Impairment
DOI:
https://doi.org/10.61841/kszydv97Keywords:
BDNF, cognitive impairment, elderly, NSEAbstract
Background: Mild and moderate cognitive impairment in the elderly leads to activity limitation and decreases quality of life. Brain-derived neurotrophic factor (BDNF) levels are decreased in the elderly with cognitive impairment. Physical exercise can promote cognitive function improvement. One of the mechanisms is through BDNF.
Objective: Analyzed the effect of dual-task Net Step Exercise (NSE) on working memory, global cognitive function, and BDNF serum levels in elderly with mild and moderate cognitive impairment.
Method: The study was a pretest-posttest control group design, which enrolled 26 elderly subjects with mild and moderate cognitive impairment, 13 subjects in the intervention (dual-task NSE) group, and 13 subjects in the control group. Before and after the study, working memory, global cognitive function, and serum levels of BDNF were examined quantitatively with an enzyme-linked immune-sorbent assay (ELISA).
Result: There was improvement of mini-mental state examination (MMSE) score (p = 0.001) and trail making test B (TMT-B) score (p = 0.03) in intervention group after 8 weeks of dual-task NSE, while there was no improvement in control group. There was a significant elevation of BDNF serum levels in the intervention group after 8 weeks of dual-task NSE (p<0.001), while there was no significant change of BDNF serum levels in the control group (p = 0.107).
Conclusion: Dual-task NSE could improve working memory and global cognitive function and also increase BDNF serum levels in the elderly with mild to moderate cognitive impairment.
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