Effect of NA-CMC Gelling Agent on Physical Properties of Hand Sanitizer with Basil Essential Oil (Ocimum sanctum L)

Authors

  • Iin Lidia Putama Mursal Buana Perjuangan Karawang University, Indonesia Author
  • Anggun Hari Kusumawati Buana Perjuangan Karawang University, Indonesia Author
  • Devi Hartianti Puspasari Buana Perjuangan Karawang University, Indonesia Author
  • Mawarnie Puspitasari Widyatama University Author

DOI:

https://doi.org/10.61841/r0ftej98

Keywords:

gelling agent, Na-CMC, physical properties, Ocimum sanctum L

Abstract

Hand sanitizers were effective and inexpensive product that can reduce of microorganims on the skin. Many hand sanitizer have contents up to 60%-95% ethanol and isopropyl alcohol, but using alcohol in hand sanitizer can cause health risks effect. The leaves of basil oil (Ocimum sanctum L.) can be used as an active ingredient for hand sanitizers because it has an antibacterial activity. The aim of this work was to determine the effects of gelling agent Na-CMC on physical properties of formulation gel hand sanitizer. The concentration that used for the Na-CMC gelling agent are 3%; 3,5%; 4%. The test of physical properties includes organoleptic, homogeneity, pH, viscosity, dispersive ability, and adhesion The results of this research on the physical properties gel hand sanitizer of basil essensial oil, showed that the increasing of gelling agent consentrasion, makes the gel getting faded, more thicker, increase of viscosity, adhesion and decrease of dispersive ability. Based on the physical properties test, (F2) with 3,5% concentration of Na-CMC is the optimal formula it caused by it suitable all the parameters of the physical properties of gel. 

Downloads

Download data is not yet available.

References

[1] Afianti, H. P., dan M. Murrukmihadi, 2015, Pengaruh Variasi Kadar Gelling Agent NA-CMC terhadap Sifat

Fisik Sediaan gel Ekstrak Etanolik Daun Kemangi (Ocimum basilicum L. Forma citratum Back.), Majalah

Farmaseutik, Volume 11 Nomor 2, pg 307-315.

[2] Ande, Baktiman, 2014, Skripsi : Pengaruh Penambahan Konsentrasi Carbopol 940 pada Sediaan Sunscreen Gel

Ekstrak Temu Giring (Curcuma heyneana Val.) Terhadap Sifat Fisik dan Stabilitas Sediaan dengan Sorbitol

sebagai Humectant, Univeritas Sanata Dharma, Yogyakarta.

[3] Ardana, M., Vebry Aeyni., dan Arsyik, I, 2015, Formulasi dan Optimasi Basis Gel NA-CMC (Hidroxy Propyl

Methyl Cellulose) dengan Berbagai Variasi Konsentrasi, J.Top. Pharm. Chem, Volume 3 Nomor 2, pg 102-108.

[4] Damayanti, A.T.R, 2016, Skripsi: Pengaruh Konsentrasi NA-CMC dan Propilen Glikol Terhadap Sifat dan Stabilitas Fisik Sediaan Gel Ekstrak Pegagan (Centella asiatica (L.) Urban), Universitas Sanata Dharma, Yogyakarta.

[5] Fujiastuti, T., dan Nining, S., 2015, Sifat Fisik dan Daya Iritasi Ekstrak Etanol Herba Pegagan (Centella asiatica L.) dengan Variasi Jenis Gelling Agent, Pharmacy Volume 12 Nomor 1, ISSN 1693-3591, pg 11-20.

[6] Garg, A., Aggarwal, D., Garg, S., dan Singla, A.K, 2002, Spreading of Semisolid Formulation, Pharmaceutical Technology, USA, pg 84-104.

[7] Hasyim, N., K.L.Pare., I. Junaid, A. Kurniati, 2012, Formulasi dan uji Efektivitas Gel Luka Bakar Ekstrak Daun Cocor Bebek (Kalanchoe pinnata L.) pada Kelinci (Oryctolagus cuniculus), Majalah Farmasi dan Farmakologi, Volume 16 Nomor 2, pg 89-94.

[8] Jabarullah, N.H. (2019) Production of olefins from syngas over Al2O3 supported Ni and Cu nano-catalysts, Petroleum Science and Technology, 37 (4), 382 – 385.

[9] Larasati, D. A., dan Ety, A., 2016, Efek Potensial Daun Kemangi (Ocimum basilicum L.) sebagai Pemanfaatan Hand Sanitizer, Majority (Medical Journal of Lampung University), Volume 5 Nomor 5, pg 124-128.

[10] Martin, A., Swrbrick, J., Cammarata, A, 1993, Physical Pharmacy, Physical Chemical Principles in The Pharmaceutical Science 2 ed 3, diterjemahkan oleh Yoshita, Universitas Indonesia Press, Jakarta.

[11] Maulina, L., dan Nining, S., 2015, Formulasi Gel Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) dengan Variasi Gelling Agent sebagai Sediaan Luka Bakar, Pharmaҫiana, Volume Nomor, pg 43-52.

[12] Rowe, R.C., Sheskey P.J., Quinn M.E, 2009, Handbook of Pharmaceutical Excipients, 6th Ed, The Pharmaceutical Press, London.

[13] Su’aida, N., Destria, I. S., Mia, F., 2017, Optimasi Sediaan Gel Fraksi Etil Asetat Buah Kasturi (Mangifera casturi Kosterm) dengan Kombinasi Basis CMC-Na dan Carbopol Menggunakan Metode Simplex Lattice Design, JCPS (Journal of Current Pharmaceutical Sciences), Volume 1 Nomor 1, ISSN 2598-2095, pg 19-24.

[14] Voigt, R, 1984, Buku Pelajaran Teknologi Farmasi edisi 5, Universitas Gadjah Mada Press, Yogyakarta, pg 560-561.

[15] Zats, J. L., dan G. P. Kushia, 1996, Gel, in Lieberman, H.A., Rieger, M.M., Banker, G.S., Pharmaceutical Dosage Forms: Disperse system Volume 2, pg 400-415, Marcel Dekker Inc, New York.

Downloads

Published

29.02.2020

How to Cite

Lidia Putama Mursal, I., Hari Kusumawati, A., Hartianti Puspasari, D., & Puspitasari, M. (2020). Effect of NA-CMC Gelling Agent on Physical Properties of Hand Sanitizer with Basil Essential Oil (Ocimum sanctum L). International Journal of Psychosocial Rehabilitation, 24(1), 8444-8450. https://doi.org/10.61841/r0ftej98