ROLE OF PLEURAL BIOPSY IN THE EVALUATION OF THE PLEURAL EFFUSION
DOI:
https://doi.org/10.61841/chm86236Keywords:
pleural biopsy, , pleural effusion,, thoracoscopy, tuberculosis, malignant pleural effusionAbstract
-In a hospital where thoracoscopy is not available, pleural biopsy can be used for the diagnosis of exudative effusion in conditi0ons where malignancy is doubted and when results of pleural effusion are not conclusive. In a country with limited resources like India pleural biopsy can still be used for the diagnosis of pleural effusion. 1.To study use of pleural biopsy in evaluation of pleural effusion.2. To correlate the pleural biopsy with biochemical and cytological findings of pleural fluid.3. To find the complications of pleural biopsy. An observational cross sectional study will be conducted in Acharya Vinoba Bhave Rural Hospital among 70 patients admitted with exudative pleural effusion. Pleural biopsy will be done and pleural fluid investigations will be send. Cause of pleural effusion can be obtained from the pleural biopsy. Malignancy and tuberculosis are the most frequent reasons of pleural effusion according to previous studies. Whether pleural biopsy gives definitive diagnosis as compared to pleural fluid cytology or pleural fluid CBNAAT. Pleural biopsy is associated with minimal post procedure complications Pleural Biopsy helps in the identifying the etiology of undiagnosed pleural effusion. Complications associated with pleural biopsy is less. Closed pleural biopsy helps identifying cause of the exudative pleural effusion when thoracoscopy is not available.
Downloads
References
1. Light RW, Diagnostic principles in pleural disease. Eur Respir J 1997;10;476-81
2. Saguil A, Wyrick K, Hallgren J. Diagnostic Approach to pleural effusion. Am Fam physician 2014;90(2): 99-104
3. Hooper C, Lee Y C, Maskell N. Investigation of a unilateral pleural effusion in adults. British Thoracic Society Pleural disease guideline 2010.Thorax 2010,65 suppl 2: ii 4-17
4. Sudipta Pandit, Arunabha Datta. Role of pleural biopsy in etiological diagnosis of pleural effusion. Lung India 2010 ;27 (4):202-204.
5. Somnath Bhattacharya, Tapan D Bairagya. Closed pleural biopsy is still useful in the evaluation of malignant pleural effusion. Journal of laboratory physicians 2012;4(1):35-38.
6. Govind Singh Rajawat, Supreet Batra. Diagnostic yield and safety of closed needle pleural biopsy in exudative pleural effusion. Avicenna journal of medicine 2017;7(3):121-12
7. Robert H.Poe,Robert.H.Israel;Mark J Utell. Sensitivity, Specificity and predictive values of closed pleural biopsy. Arch Intern med.1984;144(2):325-328.
8. Gouda A M, Dalati T A, Al -Shareef NS. A comparison between Cope and Abrams needle in the diagnosis of pleural effusion. Ann Thorac Med 2006; 1:12-15. 53.
9. Dutt N,Agarwal D. Closed pleural biopsy:A victim of Western advancement. Lung India 2011:28
10. . Sharma, S. K., J. Chaubey, B. K. Singh, R. Sharma, A. Mittel, and A. Sharma. “Drug Resistance Patterns among Extra-Pulmonary Tuberculosis Cases in a Tertiary Care Centre in North India.”
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 21, no. 10 (October
2017): 1112–17. https://doi.org/10.5588/ijtld.16.0939. 24.
11. Gupta, Vivek, and Arvind Bhake. “Assessment of Clinically Suspected Tubercular Lymphadenopathy by Real-Time PCR Compared to Non-Molecular Methods on Lymph Node Aspirates.” ACTA CYTOLOGICA 62, no. 1 (February 2018): 4–11. https://doi.org/10.1159/000480064.
12. Ghorpade, Deesha, Sheetu Singh, Deepak Talwar, Sagar Chandrashekariah, Surya Kant, Rajesh Swarnakar, Srinivas Rajagopala, et al. “Post-Tuberculosis Bronchiectasis in India: Outcomes of the Indian EMBARC Registry.” EUROPEAN RESPIRATORY JOURNAL 52, no. 62 (September 15, 2018).
https://doi.org/10.1183/13993003.congress-2018.PA2748
13. Gupta, Vivek, and Arvind Bhake. “Assessment of Clinically Suspected Tubercular Lymphadenopathy by Real-Time PCR Compared to Non-Molecular Methods on Lymph Node Aspirates.” ACTA CYTOLOGICA 62, no. 1 (February 2018): 4–11. https://doi.org/10.1159/000480064.
14. “Reactive Lymphoid Hyperplasia or Tubercular Lymphadenitis: Can Real-Time PCR on Fine-Needle Aspirates Help Physicians in Concluding the Diagnosis?” ACTA CYTOLOGICA 62, no. 3 (2018): 204–
8. https://doi.org/10.1159/000488871.
15. Sharma, Surendra Kumar, Alladi Mohan, Achintya Dinesh Singh, Hridesh Mishra, Sonali Jhanjee, Ravindra Mohan Pandey, Binit Kumar Singh, et al. “Impact of Nicotine Replacement Therapy as an Adjunct to Anti-Tuberculosis Treatment and Behaviour Change Counselling in Newly Diagnosed Pulmonary Tuberculosis Patients: An Open-Label, Randomised Controlled Trial.” SCIENTIFIC REPORTS 8 (June 11, 2018). https://doi.org/10.1038/s41598-018-26990-5.
16. Sharma, S. K., R. Sharma, B. K. Singh, V. Upadhyay, and I. Mani. “A Study of Non-Tuberculous Mycobacterial (NTM) Disease Among Tuberculosis Suspects at a Tertiary Care Center in North India.” AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 199 (2019).
17. Sharma, Surendra K., and Keertan Dheda. “What Is New in the WHO Consolidated Guidelines on Drug- Resistant Tuberculosis Treatment.” INDIAN JOURNAL OF MEDICAL RESEARCH 149, no. 3 (March 2019): 309–12. https://doi.org/10.4103/ijmr.IJMR_579_19.
18. Sharma, Surendra K., and Keertan Dheda. “What Is New in the WHO Consolidated Guidelines on Drug- Resistant Tuberculosis Treatment.” INDIAN JOURNAL OF MEDICAL RESEARCH 149, no. 3 (March 2019): 309–12. https://doi.org/10.4103/ijmr.IJMR_579_19.
19. Dhar, Raja, Sheetu Singh, Deepak Talwar, Sagar Chandrashekariah, Surya Kant, Rajesh Swarnakar, Srinivas Rajagopala, et al. “Phenotypes in Bronchiectasis from the EMBARC India Registry.” EUROPEAN RESPIRATORY JOURNAL 52, no. 62 (September 15, 2018).
https://doi.org/10.1183/13993003.congress-2018.OA4952
20. Modi S, Agrawal A, Bhake A, Agrawal V. Role of adenosine deaminase in pleural fluid in tubercular pleural effusion. J Datta Meghe Inst Med Sci Univ 2018;13(4):163-167.
21. Gotarkar S, Ingole A. Knowledge of Anganwadi worker with respect to early childhood development. J Datta Meghe Inst Med Sci Univ 2018;13(4):168-170.
22. Goje K, Phatak S. Testicular torsion causing infarction of testis, ultrasonography and color Doppler imaging. J Datta Meghe Inst Med Sci Univ 2018;13(4):215-216.
23. Sarode RD, Tendolkar VD. Psychological pain as predictor of impulse control among BAMS new entrants: A correlation study. J Datta Meghe Inst Med Sci Univ 2018;13(4):171-174.
24. Mishra KK, Kelkar P, Kumar K. An interesting case of trichotillomania in a pre-school child. J Indian Assoc Child Adolesc Ment Health 2018;14(4):131-135.
25. Sthapak E, Gajbe U, Singh BR. Study of communication between musculocutaneous and median nerves in man. J Anat Soc India 2018;67: S37-S44.
26. Tripathi A, Avasthi A, Grover S, Sharma E, Lakdawala BM, Thirunavukarasu M, et al. Gender differences in obsessive-compulsive disorder: Findings from a multicentric study from northern India. Asian J Psychiatry 2018; 37:3-9.
27. Yeola ME, Gode D, Bora AK. Evaluation of abdominal malignancies by minimal access surgery: Our experience in a rural setup in central India. World J Laparoscopic Surg 2018;11(3):115-120.
28. Srivastava TK, Mishra V, Waghmare LS. Formative assessment classroom techniques (FACts) for better learning in pre-clinical medical education: A controlled trial. J Clin Diagn Res 2018;12(9):JC01-JC08.
29. Balwani M, Bawankule C, Ramteke V, Pasari A. Hepatitis C virus, directly acting antivirals and Guillain- Barré syndrome. Saudi J Kidney Dis Transpl 2018;29(5):1237-1239.
30. Balwani MR, Pasari A, Meshram A, Jawahirani A, Tolani P, Laharwani H, et al. An initial evaluation of hypokalemia turned out distal renal tubular acidosis secondary to parathyroid adenoma. Saudi J Kidney Dis Transpl 2018;29(5):1216-1219.
31. Goyal RC, Choudhari SG, Tankhiwale SR. Assessment of competency based medical internship training with ‘cumulative grade points average system’-An innovative step towards meeting ‘vision 2015’ of medical council of india. Indian J Public Health Res Dev 2018;9(8):155-162.
32. Yeola ME, Gode D, Bora AK. Diagnostic laparoscopy as an effective tool in evaluation of intra-abdominal malignancies. World J Laparoscopic Surg 2018;11(2):68-75.
33. Sharma S, Singh AD, Sharma SK, Tripathi M, Das CJ, Kumar R. Gallium-68 DOTA-NOC PET/CT as an alternate predictor of disease activity in sarcoidosis. Nucl Med Commun 2018;39(8):768-778.
34. Daigavane S, Prasad M. To observe the proportion of amblyopia among children presenting in a rural hospital in Central India. J Datta Meghe Inst Med Sci Univ 2018;13(3):119-121.
35. Gadge A, Acharya N, Shukla S, Phatak S. Comparative study of transvaginal sonography and hysteroscopy for the detection of endometrial lesions in women with abnormal uterine bleeding in perimenopausal age group. J SAFOG 2018;10(3):155-160.
36. Anjankar SD. Urethral protrusion of the distal end of shunt. J Pediatr Neurosci 2018;13(3):371-372.
37. Swarnkar M, Pandey P. Heterotopic subserosal pancreatic tissue in jejunum. Formosan J Surg 2018;51(4):167-170.
38. Choudhari MS, Sonkusale MI, Deshpande RA. Sudden cardiac arrest on 5 th day after coronary artery bypass graft surgery: Diagnostic dilemma. Ann Card Anaesth 2018;21(3):341-342.
39. Kirnake V, Arora A, Sharma P, Goyal M, Chawlani R, Toshniwal J, et al. Non-invasive aspartate aminotransferase to platelet ratio index correlates well with invasive hepatic venous pressure gradient in cirrhosis. Indian J Gastroenterol 2018;37(4):335-341.
40. Kürhade G, Nayak BS, Kurhade A, Unakal C, Kurhade K. Effect of martial arts training on IL-6 and other immunological parameters among Trinidadian subjects. J Sports Med Phys Fitness 2018;58(7-8):1110- 1115.
41. Balwani MR, Bawankule C, Khetan P, Ramteke V, Tolani P, Kute V. An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis. Saudi J Kidney Dis Transpl 2018;29(4):989-992.
42. Mohite D, Hande A, Gupta R, Chaudhary M, Mohite P, Patil S, et al. Immunohistochemical evaluation of expression pattern of p53, p63, and p73 in epithelial dysplasia. J Datta Meghe Inst Med Sci Univ 2018;13(3):122-129.
43. Rathi N, Chandak M, Mude G. Comparative evaluation of dentinal caries in restored cavity prepared by galvanic and sintered burs. Contemp Clin Dent 2018;9(5): S23-S27.
44. Gupta V, Bhake A. Reactive Lymphoid Hyperplasia or Tubercular Lymphadenitis: Can Real-Time PCR on Fine-Needle Aspirates Help Physicians in Concluding the Diagnosis? Acta Cytol 2018;62(3):204-208.
45. Zodpey S, Sharma A, Zahiruddin QS, Gaidhane A, Shrikhande S. Allopathic Doctors in India: Estimates, Norms and Projections. J Health Manage 2018;20(2):151-163.
46. Yadav S, Agrawal M, Hariharan C, Dewani D, Vadera K, Krishna N. A comparative study of serum lipid profile of women with preeclampsia and normotensive pregnancy. J Datta Meghe Inst Med Sci Univ 2018;13(2):83-86.
47. Bhinder HHPS, Kamble TK. The study of carotid intima-media thickness in prediabetes and its correlation with cardiovascular risk factors. J Datta Meghe Inst Med Sci Univ 2018;13(2):79-82.
48. Munjal R, Mudey G. Nasal carriage of Staphylococcus aureus among undergraduate medical students: Prevalence and antibiogram including methicillin resistance, inducible clindamycin resistance, and high- level mupirocin resistance. J Datta Meghe Inst Med Sci Univ 2018;13(2):91-94.
49. Mittal V, Jagzape T, Sachdeva P. Care seeking behaviour of families for their sick infants and factors impeding to their early care seeking in rural part of central India. J Clin Diagn Res 2018;12(4):SC08- SC12.
50. Choudhary S, Tarafdar P, Jawade S, Singh A. A point to note in pili torti. Int J Trichology 2018;10(2):95- 97.
51. Madke B, Gardner JM. Enhanced worldwide dermatology-pathology interaction via Facebook, Twitter, and other social media platforms. Am J Dermatopathol 2018;40(3):168-172.
52. Girish M, Rawekar A, Jose S, Chaudhari U, Nanoti G. Utility of Low Fidelity Manikins for Learning High Quality Chest Compressions. Indian J Pediatr 2018;85(3):184-188.
53. Goswami J, Balwani MR, Kute V, Gumber M, Patel M, Godhani U. Scoring systems and outcome of chronic kidney disease patients admitted in intensive care units. Saudi J Kidney Dis Transpl 2018;29(2):310-317.
54. Mohite PM, Anjankar AJ, Patnod S. Organo pHOSPHORUS pOISONING: Prognostic value of GCS score and other clinical indicators in assessing the final outcome. J Indian Acad Forensic Med 2018;40(2):197-205.
55. Mathur K, Ninave S, Patond S, Ninave S, Wankhade P. A comparative study of estimation of stature by Bertillon's system among individuals of different regions of India. J Indian Acad Forensic Med 2018;40(3):301-306.
56. Kumar S, Bhayani P, Hathi D, Bhagwati J. Hyponatremia initial presenting feature of normal pressure hydrocephalus in elderly patient: A rare case report. J Gerontology Geriatrics 2018;66(3):156-157.
57. Jaiswal S, Banait S, Daigavane S. A comparative study on peripapillary retinal nerve fiber layer thickness in patients with iron-deficiency anemia to normal population. J Datta Meghe Inst Med Sci Univ 2018;13(1):9-11.
58. Deshpande P, Gupta V, Bhake A. Methylation pattern of retrotransposons: Biomarker for human cancer. J Datta Meghe Inst Med Sci Univ 2018;13(1):66-70.
59. Phatak S, Marfani G. Galactocele ultrasonography and elastography imaging with pathological correlation. J Datta Meghe Inst Med Sci Univ 2018;13(1):1-3.
60. Swarnkar M, Agrawal A. Kimura's disease. Formosan J Surg 2018;51(1):26-28.
61. Chiwhane A, Pradeep. Study of rhythm disturbances in acute myocardial infarction. J Assoc Phys India 2018;66(January):54-58.
62. Gupta V, Bhake A. Assessment of Clinically Suspected Tubercular Lymphadenopathy by Real-Time PCR Compared to Non-Molecular Methods on Lymph Node Aspirates. Acta Cytol 2018;62(1):4-11.
63. Anjankar S. Askin's tumor in adult: A rare clinical entity. J Datta Meghe Inst Med Sci Univ 2018;13(1):54- 57.
64. Jain J, Banait S, Tiewsoh I, Choudhari M. Kikuchi's disease (histiocytic necrotizing lymphadenitis): A rare presentation with acute kidney injury, peripheral neuropathy, and aseptic meningitis with cutaneous involvement. Indian J Pathol Microbiol 2018;61(1):113-115.
65. Jain V, Waghmare L, Shrivastav T, Mahakalkar C. SNAPPS facilitates clinical reasoning in outpatient settings. Educ Health 2018;31(1):59-60.
66. Bains SK, John P, Nair D, Acharya S, Shukla S, Acharya N. Aptitude of medical research in undergraduate students of a medical university - Miles to go before we sow. J Clin Diagn Res 2017;11(12):JC07-JC11.
67. Taksande A, Meshram R, Yadav P, Lohakare A. Rare presentation of cerebral venous sinus thrombosis in a child. J Pediatr Neurosci 2017;12(4):389-392.
68. Choudhari MS, Charan N, Sonkusale MI, Deshpande RA. Inadvertent diversion of inferior vena cava to left atrium after repair of atrial septal defect - Early diagnosis and correction of error: Role of intraoperative transesophageal echocardiography. Ann Card Anaesth 2017;20(4):481-482.
69. Swarnkar M, Jain SC. Heterotopic subserosal pancreatic tissue in Jejunum-an incidental rare finding. J Krishna Inst Med Sci Univ 2017;6(4):105-108.
70. Taksande A, Meshram R, Yadav P, Borkar S, Lohkare A, Banode P. A rare case of Budd Chiari syndrome in a child. Int J Pediatr 2017;5(10):5809-5812.
71. Gupta V, Bhake A. Diagnosis of clinically suspected and unsuspected tubercular lymphadenopathy by cytology, culture, and smear microscopy. Indian J Tuberc 2017;64(4):314-317.
72. Gupta V, Bhake A. Clinical and cytological features in diagnosis of peripheral tubercular lymphadenitis – A hospital-based study from central India. Indian J Tuberc 2017;64(4):309-313.
73. Sharma SK, Chaubey J, Singh BK, Sharma R, Mittal A, Sharma A. Drug resistance patterns among extra- pulmonary tuberculosis cases in a tertiary care centre in North India. Int J Tuberc Lung Dis 2017;21(10):1112-1117.
74. Jyoti J, Nitin V, Shashank B, Pradeep D. Gamma glutamyl transferase levels in patients with acute coronary syndrome: A cross-sectional study. J Cardiovasc Dis Res 2017;8(4):121-125.
75. Ali S, Ghewade B, Jadhav U, Cladius S. Study of serum interferon gamma in tubercular pleural effusions. J Datta Meghe Inst Med Sci Univ 2017;12(2):93-98.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.