LONG TERM EFFECT OF CAFFEINE INTAKE ON SERUM ESTROGEN LEVELS AMONG FEMALES OF CHILD BEARING AGE- A REVIEW

Authors

  • Kausalyah Krisna Malay Graduate Student, Saveetha Dental College and Hospital, Saveetha Institute of Medical And Technical Sciences, Chennai- 600077. India Author
  • Sheersha Malay Lecturer, Department of Biochemistry, Saveetha Dental College and Hospital, 162, Poonamalle high road, Velappanchavadi, Chennai- 600077, India Author
  • Pavithra Priyadarshoni S Tutor, Saveetha Dental College and Hospital, Saveetha Institute of Medical And Technical Sciences, Chennai- 600077. India Author
  • Dhanraj Ganapathy Professor and Head Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical And Technical Sciences, Chennai – 600077 Tamil Nadu, India Author

DOI:

https://doi.org/10.61841/y79yz950

Keywords:

Estrogen, caffeine, hormonal changes, females, endometriosis, dimethylxanthines

Abstract

Many studies have indicated that caffeine consumption among women of child-bearing age has its effect on estrogen levels. The variation in estrogen levels associates with disorders such as endometriosis, osteoporosis, endometrial, breast and ovarian cancers. Long term caffeine consumptions potentials to influence estrogen levels over a long period of time and thus it make sense to take caffeine consumption into account when designing studies to understand these disorders. Caffeine, and probably dimethylxanthines, is ergogenic for most of the women. The mechanisms involve in the mode of actions of these compounds are varies and complex and extend well beyond the traditional explanation of sparing of muscle glycogen to probably involve fundamental aspects of muscle contractility. This probability mostly affects the level of estrogen in women especially in women with child bearing age. Caffeine acts as the suppressor for the estrogen hormone. Purpose of this review is to reveal the actual responces of caffeine towards the estrogen hormones.

Downloads

Download data is not yet available.

References

1. Anderson BL, Juliano LM, Schulkin J. Caffeine’s implications for women’s health and survey of obstetrician-gynecologists’ caffeine knowledge and assessment practices. J Womens Health (Larchmt). 2009;18(9):1457–66.

2. Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci USA. 1989;86(20):7696–700.

3. Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Caffeinated and alcoholic beverage intake in relation to ovulatory disorder infertility. Epidemiology. 2009;20(3):374–81.

4. Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H. Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006;295(10):1135–41.

5. Eliassen AH, Hankinson SE. Endogenous hormone levels and risk of breast, endometrial, and ovarian cancers: prospective studies. Adv Exp Med Biol. 2008;630:148–65.

6. Eliassen AH, Missmer SA, Tworoger SS, Spiegelman D, Barbieri RL, Dowsett M, Hankinson SE. Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst. 2006;98(19):1406–15.

7. Fenster L, Quale C, Waller K, Windham GC, Elkin EP, Benowitz N, Swan SH. Caffeine consumption and menstrual function. Am J Epidemiol. 1999;149(6):550–7.

8. Frary CD, Johnson RK, Wang MQ. Food sources and intakes of caffeine in the diets of persons in the United States. J Am Diet Assoc. 2005;105(1):110–3.

9. Goldin BR, Adlercreutz H, Gorbach SL, Woods MN, Dwyer JT, Conlon T, et al. The relationship between estrogen levels and diets of Caucasian American and Oriental immigrant women. Am J Clin Nutr. 1986;44(6):945–53.

10. Grodstein F, Goldman MB, Ryan L, Cramer DW. Relation of female infertility to consumption of caffeinated beverages. Am J Epidemiol. 1993;137(12):1353–60.

11. Howards PP, Schisterman EF, Wactawski-Wende J, Reschke JE, Frazer AA, Hovey KM. Timing clinic visits to phases of the menstrual cycle by using a fertility monitor: the BioCycle Study. Am J Epidemiol. 2009;169(1):105–12.

12. Kinney A, Kline J, Kelly A, Reuss ML, Levin B. Smoking, alcohol and caffeine in relation to ovarian age during the reproductive years. Hum Reprod. 2007;22(4):1175–85.

13. Kotsopoulos J, Eliassen AH, Missmer SA, Hankinson SE, Tworoger SS. Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women. Cancer. 2009;115(12):2765–74.

14. Kotsopoulos J, Vitonis AF, Terry KL, De Vivo I, Cramer DW, Hankinson SE, Tworoger SS. Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer. Cancer Causes Control. 2009;20(3):335–44.

15. Lin KM, Poland RE. Ethnicity, culture, and psychopharmacology. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: The Fourth Generation of Progress. Brentwood, TN: American College of Neuropsychopharmacology; 2000.

16. Lucero J, Harlow BL, Barbieri RL, Sluss P, Cramer DW. Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use. Fertil Steril. 2001;76(4):723–9.

17. Lurie G, Maskarinec G, Kaaks R, Stanczyk FZ, Le Marchand L. Association of genetic polymorphisms with serum estrogens measured multiple times during a 2-year period in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2005;14(7):1521–7.

18. Marsh EE, Shaw ND, Klingman KM, Tiamfook-Morgan TO, Yialamas MA, Sluss PM, Hall JE. Estrogen levels are higher across the menstrual cycle in African-American women compared with Caucasian women. J Clin Endocrinol Metab. 2011;96(10):3199–206.

19. McCusker RR, Goldberger BA, Cone EJ. Caffeine content of specialty coffees. J Anal Toxicol. 2003;27(7):520–2.

20. Miao YL, Shi LH, Lei ZL, Huang JC, Yang JW, Ouyang YC, Sun QY, Chen DY. Effects of caffeine on in vivo and in vitro oocyte maturation in mice. Theriogenology. 2007;68(5):640–5.

21. Mizutani T. PM frequencies of major CYPs in Asians and Caucasians. Drug Metab Rev. 2003;35(2–3):99–106.

22. Nagata C, Kabuto M, Shimizu H. Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women. Nutr Cancer. 1998;30(1):21–4.

23. Palacios N, Weisskopf M, Simon K, Gao X, Schwarzschild M, Ascherio A. Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson’s disease in men and women. Parkinsonism Relat Disord. 2010;16(6):370–5.

24. Sachse C, Brockmoller J, Bauer S, Roots I. Functional significance of a C/A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol. 1999;47(4):445–9.

25. Sowers MR, Wilson AL, Kardia SR, Chu J, Ferrell R. Aromatase gene (CYP19) polymorphisms and endogenous androgen concentrations in a multiracial/multiethnic, multisite study of women at midlife. Am J Med. 2006;119(9 Suppl 1):S23–30.

26. Södergård R, Bäckström T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem. 1982;16(6):801–10.

27. Subashri A, Vishnu Priya V. Awareness of consuming caffeine in pregnant women. Int J Pharm Bio Sci. 2017;8(1B):74–8.

28. Tworoger SS, Gertig DM, Gates MA, Hecht JL, Hankinson SE. Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Cancer. 2008;112(5):1169–77.

29. Yamazaki H, Shaw PM, Guengerich FP, Shimada T. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes. Chem Res Toxicol. 1998;11(6):659–65.

30. Yen SSC, Strauss JF, Barbieri RL. Yen and Jaffe’s Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management. 5th ed. Philadelphia: Elsevier/Saunders; 2004.

31. Sowers MR, Wilson AL, Kardia SR, Chu J, Ferrell R. Aromatase gene (CYP19) polymorphisms and endogenous androgen concentrations in a multiracial/multiethnic, multisite study of women at midlife. Am J Med Sci. 2006;119:S23–30.

32. B. John Rozar Raj, Vishnu Priya V, Gayathri B. Relationship between coffee consumption and cancer – A Review. J Pharm Sci Res. 2016;8(6):424–7.

33. Speroff L, Glass RH, Kase NG. Clinical Gynecologic Endocrinology and Infertility. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 1999.

34. Fenster L, Fortier I, Mills J, Dominguez-Rojas V, Rondo P. Combined studies on caffeine and reproductive outcomes. Am J Epidemiol. 1991;134(6):1411–4.

Downloads

Published

16.12.2019

How to Cite

Malay, K. K., Malay, S., Priyadarshoni S, P., & Ganapathy, D. (2019). LONG TERM EFFECT OF CAFFEINE INTAKE ON SERUM ESTROGEN LEVELS AMONG FEMALES OF CHILD BEARING AGE- A REVIEW . International Journal of Psychosocial Rehabilitation, 23(6), 1404-1412. https://doi.org/10.61841/y79yz950