Endometrial Hyperplasia Possibilities of Diagnostic Clarification

Authors

  • Sergey A. Levakov Doctor of Medical Sciences, Professor, Head of the Department of Obstetrics and Gynecology at the Institute of Clinical Medicine, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Street, Moscow, Russia Author
  • Nataliya A. Sheshukova Doctor of Medical Sciences, Professor of the Department of Obstetrics and Gynecology at the Institute of Clinical Medicine, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Street, Moscow, Russia Author
  • Elizaveta A. Obukhova Assistant at the Department of Obstetrics and Gynecology at the Institute of Clinical Medicine, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Street, Moscow, Russia Author

DOI:

https://doi.org/10.61841/ff9pr162

Keywords:

Endometrial Hyperplasia, Chronic Endometritis, Combination of Endometrial Hyperplasia

Abstract

The present article is dedicated to the evaluation of histological and immunohistochemical methods in the differential diagnostics of endometrial hyperplasia and its association with chronic endometritis. The study included 350 patients aged 45–55 years old. The study entry criteria included abnormal uterine bleeding (85.6%) and/or the presence of sonographic signs of pathological changes in the endometrium (14.4%). Patients underwent endometrial curettage and hysteroscopy with histological examination of endocervical and uterine scrapings. By the results of histological examination, 2 groups were formed: the group of comparison (30 patients) included patients that did not have pathological alterations in the endometrium by the results of the morphological examination, and the main group (320 patients) included histologically confirmed endometrial hyperplasia. Further, immunohistochemical examination of the obtained endometrial tissue was performed. It was established that it is not always possible to diagnose chronic endometritis with the histological method. This method does not differentiate reactive hyperplasia from benign endometrial hyperplasia. For differential diagnostics of endometrial hyperplasia and its association with chronic endometritis, it is necessary to apply the immunohistochemical method, which will allow for the proper choice of the treatment tactics. 

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References

[1] Moore E, Shafi M. Endometrial hyperplasia. Obstetrics, Gynaecology and Reproductive

Medicine. 2013;23(3):88-93.

[2] Kondrikov NI, Asaturova AB, Mogirevskaya OA. Reproduction of diagnoses of endometrial hyperplasia

using WHO classification and its modification. Obstetrics and Gynecology (Russian) 2011; No. 3:42-46.

[3] Emon G, Beckman MW, Schmidt D, Mallmann P. New WHO classification of endometrial hyperplasias.

Geburtshilfe Frauenheilkd 2015;75:135-136.

[4] Lax SF. Endometritis: Rare disease with clinical importance? Pathologe (German) 2016;37:521-525.

[5] Socolov D, Socolov R, Lupascu IA et al. Immunohistochemistry in endometrial hyperplasia and

endometrial adenocarcinoma. Rev Med Chir Soc Med Lasi 2016;120:355-62.

[6] Truskinovsky AM, Lifschitz-Mercer B, Czernobilsky B. Hyperplasia and carcinoma in secretory

endometrium: a diagnostic challenge. Int J Gynecol Pathol. 2014 Mar;33(2):107-13.

[7] Sukhikh GT, Shueshalina AV. Chronic endometritis, М., 2010, p. 64.

[8] Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT. New concepts for an old problem:

the diagnosis of endometrial hyperplasia. Hum Reprod Update. 2016; Dec 4 [Epub ahead of print].

[9] Upson K, Allison KH, Reed SD, et al. Biomarkers of progestin therapy resistance and endometrial

hyperplasia progression. Am J Obstet Gynecol 2012;207:36.e1-8.

[10] Kondrikov NI, Asaturova AB, Mogirevskaya OA. Reproduction of diagnoses of endometrial hyperplasia

using WHO classification and its modification. Obstetrics and Gynecology (Russian) 2011; No. 3:42-46.

[11] Emons G, Beckmann MW, Schmidt D, Mallmann P; Uterus commission of the Gynecological Oncology

Working Group (AGO). New WHO classification of endometrial hyperplasias. Geburtshilfe und

Frauenheilkunde. 2015;75(2):135-136. https://doi.org/10.1055/s-0034-1396256

[12] Bantysh B.B. Immunological peculiarities of epithelial-stromal associations in patients with glandular

endometrial hyperplasia. Thesis. М., 2011. p. 24.

[13] Chistyakova GN, Remizova II, Melkozerova OA, Pogorelko DV, Dankova IV, Esareva AV. Local

immunity status and apoptosis reactions in endometrium of women with a history of non-developing

pregnancy. Annals of Clinical and Laboratory Research. 2017;5(3):198. Accessed June 1, 2018.

[14] Masjeed NMA, Khandeparkar SGS, Joshi AR, Kulkarni MM, Pandya N. Immunohistochemical Study of

ER, PR, Ki67, and p53 in endometrial hyperplasias and endometrial carcinomas. Journal of Clinical and

Diagnostic Research. 2017;11(8):31-34.

[15] Song D, Feng X, Zhang Q, Xia E, Xiao Y, Xie W, Li TC. Prevalence and confounders

of chronic endometritis in premenopausal women with abnormal bleeding or reproductive failure. Reprod

Biomed Online. 2018 Jan;36(1):78-83.

[16] Saad FA, Torres M, Wang Het al Intracellular lysis oxidase: effect of a specific inhibitor on nuclear mass

in proliferating cells.// Biochem Biophys Res Commun. 2010 Jun 11;396(4):944-9. Epub 2010 May 9.

[17] Taylor MA, Amin JD, Kirschmann DA, Schiemann WP. Lysyl oxidase contributes to

mechanotransduction-mediated regulation of transforming growth factor-β signaling in breast cancer cells.

// Neoplasia.- May;13(5):406-18.

[18] Fedotova AS. Development of prognostic criteria in the development of atypical endometrial hyperplasia.

Thesis. М., 2012. p. 24.

[19] Chandra V, Kim JJ, Benbrook DM, Dwivedi A, Rai R. Therapeutic options for management of endometrial

hyperplasia. Journal of Gynecologic Oncology. 2016;27(1):8-15.

[20] Gallos I. D., Alazzam M., Clark T. J., et al. Management of endometrial hyperplasia. Green-top Guideline

№ 67. RCOG/BSGE Joint Guideline, 2016. 30 p.

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Published

31.07.2020

Issue

Vol. 24 No. 5 (2020): 24 (5) 2020

Section

Articles

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How to Cite

A. Levakov, S., A. Sheshukova, N., & A. Obukhova, E. (2020). Endometrial Hyperplasia Possibilities of Diagnostic Clarification. International Journal of Psychosocial Rehabilitation, 24(5), 4767-4777. https://doi.org/10.61841/ff9pr162