Anogenital Lichen Sclerosus: Literature Review and 12-patient Clinical Series in Children
DOI:
https://doi.org/10.61841/hnenaz03Keywords:
Clinical Series, Literature Review, Anogenital LichenAbstract
Background and Objectives: Anogenital lichen sclerosus is of infrequent occurrence in children. The presented research is aimed at verifying clinical features and treatment approaches to anogenital lichen sclerosus in children and adolescents.
Methods: We conducted a retrospective analysis of clinical presentations and treatment responses of 12 patients with anogenital lichen sclerosus; all stages of the study were retrospectively registered.
Findings: 41% of the patients had extragenital morphea. 3 children were successfully treated with tacrolimus 0.03% ointment; due to the resistance to local steroid treatment, the others received systemic therapy with corticosteroids, penicillamine, or methotrexate; the remission was gained in all cases.
Conclusions: Children with anogenital lichen sclerosus often have extragenital morphea backgrounded by immunological activity. The data suggest that step-changing therapy in anogenital lichen sclerosus should start with local topic steroids and tacrolimus ointment, followed by systemic immunosuppressive medications.
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