Association between Plasma Transfusion and Clinical Outcome in Critically ill Children at Zagazig University Hospital
Background:Plasma is frozen for storage to preserve the level of coagulation factors. It is named “fresh-frozen plasma” if refrigerated within 8 hours of collection, and “frozen plasma” if within 24 hours. Currently available evidence derived from retrospective studies suggests that plasma transfusions are independently associated with an increased morbidity and mortality in adults and children. The aim of the study was to decrease morbidity in critically ill children through achieving the following objectives;identification of patient characteristics for plasma transfusions, identification the indications of plasma transfusions in critically ill children, and assessment the effect of plasma transfusion on coagulation tests.MethodsThis was prospective Cohort study which conducted in PICU at Zagazig University Hospital including 54 patients with any eligible patient for whom at least one plasma transfusion was administered on any study day was included unless one of the exclusion criteria exists. Results:Mean age of studied children 36.8±43 months with range from 40 days to 168 months, 51.9% of them were girls and the mean weight of them is 13±10kg.Common reasons for PICU admission were CNS diseases (29.5%) followed by Respiratory infection and organs failure (24.1%).50 % of plasma transfusion due to bleeding, 40.7% due to hypoalbuminemia, lastly 9.3% of plasma transfusion due to physician conceptions.There is statistically insignificant difference between indication of plasma transfusion and age, sex and children weight, p>0.05.There is statistically insignificant difference between indication of plasma transfusion at different causes and percent of deaths.Conclusion: Bleeding was the most common cause of plasma transfusion followed by hypoalbuminemia and doctors believes.Plasma transfusion does not statistically affect the mortality, although there was little increase in mortality over the predictive mortality by SOFA score.