Total phospholipids and L-Carnitineas predictors of Spontaneous Closure of Atrial Septal Defect and Ventricular Septal Defect in Children at Zagazig University hospitals

Background: Congenital heart defects (CHD) are common in children. Ventricular septal defect (VSD) is the most common congenital heart defect.Atrialseptal defect (ASD) is a common congenital disorder with a prevalence of approximately 2 per 1,000 live births. phospholipids and the L-carnitine levels may have a valuable and important role in the pathogenesis and prognosis of congenital heart disease The aim was to assess the role of l.carnitine and phospholipids as predictors of spontaneous closure of atrial septal defects and ventricular septal defects. Patients and methods: this was a cohort study whichincludedthirty children divided into two groups: ASD group and VSD group.Measurement of serum L.carnitine and total phospholipids were doneResults: there was statistically significant higher total phospholipid among ASD patients with spontaneous closure than regression to ≤ 3 mm than residual >3 mm with no statistically significant difference regarding L. Carnitine. There was statistically significant higher L. Carnitine among the VSD patients with regression to ≤ 3 mm than residual >3 mm. Total phospholipids and L-Carnitine were the statistically significant predictor factors for spontaneous closure of ASD and VSD among the studied group, Conclusion: Total phospholipids and LCarnitine were the statistically significant predictor factors for spontaneous closure of ASD and VSD among the studied group.