Serum Magnesium Level Relationship With Coronary Artery Ectasia
Background: Coronary artery ectasia (CAE) without specific symptoms is the localised or diffuse swelling of the epicardial coronary arteries to at least 1.5 times the adjacent normal coronary segment. Magnesium, the second most abundant intracellular cation, is an essential element that plays a crucial role in cardiac and vascular functions. The aim of the study is to assess the vasodilatory effect of (Mg2+) in the pathogenesis of Ectasia. Methods: This case control study was carried out in zagazig university hospital from December 2018 to May 2019 included 84 selected patients who were admitted to coronary care unit for Diagnostic coronary angiography. Study patients were divided into 4 groups sample each group 21 patients. Laboratory investigations including complete blood cell count, RBS, lipid profile and serum creatinine and (MG2+) level were measured. Results: There was statistically non-significant difference regarding Hypertension, DM, dyslipidemia, smoking and family history of coronary artery disease with the four groups. When comparing serum creatinine in-between the four groups, it was of no statistically significant difference. Meanwhile as regarding serum Magnesium between the four groups, it was of high statistically significant difference with mean and SD of 1.69 ± 0.14, 2.06 ± 0.18, 1.7 ± 0.15 and 1.84 ± 0.14 receptively. cut-off value considering prediction of CAE in reference to normal control group for serum (Mg2+) is >1.8 with 80.95% sensitivity and 71.43% specificity. Meanwhile, sensitivity decreases to 71.43% and specificity increases to 92.06% when the cut-off value increased to >1.9.Conclusion: (Mg2+) level is highly predictive in the development of coronary artery ectasia in both obstructive and non obstructive coronary lesion.