Serum uric acid as a diagnostic marker in metabolic syndrome children
Background:Pathogenesis of metabolic syndrome is very complex. Several studies support the concept that oxidant/antioxidant imbalance may play an important role in its manifestations. Uric acid (UA) is a circulating marker for oxidative damage.The study aimed to investigate the potential association of UA and metabolic syndrome.Methods:From 129 random obese pediatric patients we enrolled 26 patients with metabolic syndrome randomly with percentage of 20.1% , and take matched control with same number. In Our Study we have evaluated 26 obese prepubertal children with metabolic syndrome. A control group of twenty six were taken. All children were subjected to full history taking, clinical examination including: anthropometric (waist circumference and body mass index) and blood pressure measurement, Lipid profile and serum uric acid levels were determined . Results:there was statistical significant increase in anthropometric measures, systolic blood pressure (SBP) and diastolic blood pressure (DBP), plasma glucose level (FPG),lipid profile (triglycerides, total cholesterol and low density lipoproteins (LDL) and Uric acid compared with control. In obese metabolic patients , there was positive correlation between body mass index, waist circumference, SBP, DBP,FBG, triglycerides, total cholesterol, LDL and serum UA, but significant negative correlation of serum UA and high density lipoprotein.UA at a level of 4.3 was the best cut- off value for metabolic patients with sensitivity 70% and specificity 96.3%, and this maximizing sensitivity and specificity to predict future metabolic syndrome and their area under the curve was 0.79.Conclusion: Serum uric acid is a good diagnostic marker in metabolic syndrome children.