Evaluation of Serum Annexin A1 Level in Children with Bronchial Asthma and its Relation to Disease Severity

Background: Bronchial asthma (BA) is a highly prevalent disease. Asthma is considered a multifactorial disorder that results from interaction between multiple genetic and environmental factors, the main pathology in asthma is chronic inflammation in the air way. Annexin A1 (ANXA1) is a glucocorticoidinduced protein with multiple functions in the regulation of inflammatory cell activation. The aim of this work was to evaluate Annexin A1 levels in the blood of asthmatic patients. Methods: This is a case-control study was performed for one year duration in the period from September 2018 to August 2019.This study carried out at Pediatric Department at Zagazig University Hospitals. This study included 100 children that were divided into 2 groups: Cases group (80 asthmatic children). Control group (20 age and sex matched healthy children). All patients in the study were subjected to: history, examination and Laboratory investigations (Serum Annexin A1 level)Results: Bronchial asthma was more common and severe in urban than rural residence. Parent consanguinity was significantly associated with risk factors for asthma. There is a statistically significant higher annexin A1 among cases than control group. Conclusion: Serum annexin A1 was higher in asthmatic children than controls.