Assessment of Serum Osteopontin Level in Children with Bronchial Asthma and its Relation to Disease Severity

Background:Many different mediators have been implicated in asthma and they may have a variety of effects on the airways which could account for all of the pathological features of allergic diseases. we aimed to assess Osteopontin(OPN) level in children with bronchial asthma.Methods:Our study done at Pulmonology unit Pediatric department of Zagazig University.Our study carried out on 190 children divided into 2 age groups ≤ 5 years and > 5 years. Each age group divided into 5 subgroups according to different severities of asthma into intermittent, mild, moderate and severe persistantasthma with healthy control group. serum OPN level were done for patients and controls.Results:we found that OPN show high significant difference between asthmatic and control group. Also, we reported that there was high significant difference between the control and asthmatic as Osteopontin in <5 age group and in 5-12 age group.At cut off point >14.8, area under the curve was 0.937, sensitivity was 97.8%, specificity 95.7%, PPV 96.4% and NPV 94.3%. Conclusion: The present study has shown that asthma patients exhibit higher serum OPN levels than controls.. Serum OPN is a promising biomarker in the diagnosis of bronchial asthma.