EVALUATION OF BIOPHARMACEUTICAL AND PHARMACOLOGICAL PROPERTIES OF COMBINED TERNARY COMPONENTIAL ANALGESIC TABLETS

This study aimed to investigate the biopharmaceutical and the pharmacological features of the recommended combined tablets using in vivo and in vitro methodology. We previously developed technology obtaining combined ternary tablets with a potential analgesic effect. In vitro experimental analyses were performed on a Rotating Basket instrument included in the State Pharmacopoeia XI (SPh XI). Based on the results of studying the effect of pH on the dissolution rate of the recommended tablets, the use of an neutral medium - purified water is recommended for further studies. From a biopharmaceutical point of view, the basket rotation speed is 100 turnover per minutes. The acute toxicity of the compared drugs was studied by the generally accepted method described in the literature, a single administration with the determination of the toxicity class. The analgesic effect of the drug was studied on white outbred mice, in the amount of 18 animals, weighing 20-23 grams. A specific pain reaction - “cramps” (characteristic movements of animals, including contractions of the abdominal muscles, alternating with their relaxation, stretching of the hind limbs and flexing of the back) were caused by intraperitoneal administration of 0.75% acetic acid (0.1ml/10g body weight). The antipyretic effect of the drugs was evaluated in rats weighing 180-200 g. Body temperature excited by intravenous administration of Pyrogenal. The experimental study of the indicators of acute toxicity, and specific activity of the recommended combined tablets performed in comparison with the tablets Metamizole Sodium 500 mg tablets(under abrand name “Analgin”).