Comparison of Anticardiolipin Antibodies Titer in Preeclampsia and Normal Pregnancy: A Case- Control Study

Background and Aim: Regarding the high prevalence of pre-eclampsia and its complications and also due to conflicting reports about the role of antiphospholipid antibodies, particularly anticardiolipin antibody, the aim of this study was to compare the anti-cardiolipin antibody titers in preeclampsia and normal pregnancy. Material and Methods: In this cross-sectional study, 220 pregnant women in their third trimester were evaluated in Zahedan Ali ebn Abi Talib (AS) hospital in 2013. Participants were divided in two groups preeclapmtic pregnant and normal pregnant as the control group. Sampling method was simple and available method. Anticardiolipin IgG and IgM levels were measured in two groups. Samples were analysed by simple and available methods. Independent T- test was used for data analysis. P-value less than 0.05 was considered as significant. Results: The mean age of pregnant women was 26.1±6.2 years. The gestational age was 37 ±2.1 and 38± 1.9 weeks in the Controls and Preeclampsia groups, respectively (P=0.14). The mean of IgM titer of anticardiolipin antibody in preeclampsia group was 1.85±0.84 Μg/L and in control group 2.21±1.61 Μg/L, which no significant difference was found between two groups (P=0.53). The mean of IgG titer of anti-cardiolipin antibody in preeclampsia group was 2.48±1.16 Μg/L and in control group 2.13±0.54 Μg/L and again no statistically significant difference was observed (P=0.34). Conclusions: there was no correlation between anti-cardiolipin antibody titers in pregnant women with preeclampsia compared with normal pregnant women.